RNF169 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006974Biological processDNA damage response
GO_0016567Biological processprotein ubiquitination
GO_2000780Biological processnegative regulation of double-strand break repair
GO_0006302Biological processdouble-strand break repair
GO_0005730Cellular componentnucleolus
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0031491Molecular functionnucleosome binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061649Molecular functionubiquitin-modified histone reader activity
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF169
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169)
SynonymsKIAA1991
DescriptionFUNCTION: Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization . Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 . E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. .

AccessionsENST00000299563.5
Q8NCN4
ENST00000527301.1
H0YEQ1