IFFO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990166Biological processprotein localization to site of double-strand break
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_1990683Biological processDNA double-strand break attachment to nuclear envelope
GO_0016363Cellular componentnuclear matrix
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005637Cellular componentnuclear inner membrane
GO_0005882Cellular componentintermediate filament
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIFFO1
Protein nameIntermediate filament family orphan 1
IFFO1 protein
Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103)
SynonymsIFFO
DescriptionFUNCTION: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) . Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation . Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites . .

AccessionsENST00000356896.8 [Q0D2I5-5]
A0A087WZ16
ENST00000396840.6 [Q0D2I5-1]
ENST00000465801.5
E9PPX7
ENST00000336604.8 [Q0D2I5-4]
Q6P593
ENST00000619571.5
Q0D2I5
ENST00000487279.6 [Q0D2I5-3]