Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 8 studies | 31% ± 15% | |
non-classical monocyte | 5 studies | 18% ± 3% | |
epithelial cell | 5 studies | 37% ± 16% | |
glutamatergic neuron | 4 studies | 46% ± 7% | |
kidney loop of Henle epithelial cell | 4 studies | 24% ± 7% | |
renal principal cell | 4 studies | 26% ± 5% | |
type I pneumocyte | 3 studies | 20% ± 2% | |
type II pneumocyte | 3 studies | 18% ± 2% | |
GABAergic neuron | 3 studies | 29% ± 6% | |
dendritic cell | 3 studies | 19% ± 0% | |
club cell | 3 studies | 22% ± 6% | |
transit amplifying cell | 3 studies | 37% ± 26% | |
interneuron | 3 studies | 38% ± 9% | |
myoepithelial cell | 3 studies | 47% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1136.86 | 1443 / 1445 | 100% | 39.41 | 183 / 183 |
lung | 100% | 1329.89 | 577 / 578 | 100% | 40.71 | 1155 / 1155 |
breast | 100% | 1628.54 | 459 / 459 | 99% | 50.71 | 1108 / 1118 |
thymus | 100% | 1238.51 | 653 / 653 | 99% | 30.66 | 597 / 605 |
ovary | 98% | 668.37 | 177 / 180 | 100% | 32.76 | 428 / 430 |
kidney | 100% | 3328.17 | 89 / 89 | 98% | 30.83 | 880 / 901 |
uterus | 100% | 1733.71 | 170 / 170 | 98% | 41.39 | 448 / 459 |
pancreas | 99% | 815.66 | 326 / 328 | 98% | 20.85 | 174 / 178 |
intestine | 100% | 993.56 | 966 / 966 | 96% | 19.63 | 505 / 527 |
stomach | 100% | 711.95 | 358 / 359 | 94% | 20.16 | 269 / 286 |
brain | 97% | 478.55 | 2559 / 2642 | 95% | 18.61 | 669 / 705 |
bladder | 100% | 1072.29 | 21 / 21 | 90% | 22.38 | 456 / 504 |
skin | 100% | 1710.10 | 1808 / 1809 | 86% | 18.56 | 408 / 472 |
prostate | 100% | 1035.46 | 244 / 245 | 86% | 10.23 | 434 / 502 |
adrenal gland | 100% | 750.43 | 258 / 258 | 77% | 10.48 | 178 / 230 |
liver | 86% | 527.95 | 194 / 226 | 54% | 8.52 | 218 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.64 | 29 / 29 |
tonsil | 0% | 0 | 0 / 0 | 100% | 50.94 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.22 | 1 / 1 |
adipose | 100% | 919.27 | 1202 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 651.39 | 240 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 727.11 | 1326 / 1335 | 0% | 0 | 0 / 0 |
heart | 86% | 359.48 | 741 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 58% | 845.48 | 537 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 39% | 3.96 | 31 / 80 |
muscle | 18% | 57.22 | 147 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010792 | Biological process | DNA double-strand break processing involved in repair via single-strand annealing |
GO_0006281 | Biological process | DNA repair |
GO_0001835 | Biological process | blastocyst hatching |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0051301 | Biological process | cell division |
GO_0110025 | Biological process | DNA strand resection involved in replication fork processing |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0051321 | Biological process | meiotic cell cycle |
GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
GO_0035825 | Biological process | homologous recombination |
GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0005654 | Cellular component | nucleoplasm |
GO_0017053 | Cellular component | transcription repressor complex |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0070533 | Cellular component | BRCA1-C complex |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0000014 | Molecular function | single-stranded DNA endodeoxyribonuclease activity |
GO_0005515 | Molecular function | protein binding |
GO_0003684 | Molecular function | damaged DNA binding |
Gene name | RBBP8 |
Protein name | RB binding protein 8, endonuclease DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) DNA endonuclease RBBP8 |
Synonyms | CTIP |
Description | FUNCTION: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway . HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse . Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) . Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA . Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage . During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging . . |
Accessions | ENST00000581687.1 J3QL00 ENST00000327155.10 [Q99708-1] J3KSA4 ENST00000399721.6 ENST00000582354.5 ENST00000583057.1 V9GZ40 ENST00000577445.1 J3QSH7 A0A140TA82 ENST00000583700.5 I6L8A6 J3QL93 J3QLW6 ENST00000399725.6 [Q99708-3] J3QRM0 F6Q6H0 ENST00000585177.1 J3QLH2 ENST00000579124.5 ENST00000577588.5 ENST00000360790.9 Q99708 ENST00000399722.6 [Q99708-1] ENST00000581819.5 |