RBBP8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010792Biological processDNA double-strand break processing involved in repair via single-strand annealing
GO_0006281Biological processDNA repair
GO_0001835Biological processblastocyst hatching
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051301Biological processcell division
GO_0110025Biological processDNA strand resection involved in replication fork processing
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051321Biological processmeiotic cell cycle
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0035825Biological processhomologous recombination
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0070533Cellular componentBRCA1-C complex
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0046872Molecular functionmetal ion binding
GO_0000014Molecular functionsingle-stranded DNA endodeoxyribonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameRBBP8
Protein nameRB binding protein 8, endonuclease
DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)
DNA endonuclease RBBP8
SynonymsCTIP
DescriptionFUNCTION: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway . HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse . Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) . Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA . Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage . During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging . .

AccessionsENST00000581687.1
J3QL00
ENST00000327155.10 [Q99708-1]
J3KSA4
ENST00000399721.6
ENST00000582354.5
ENST00000583057.1
V9GZ40
ENST00000577445.1
J3QSH7
A0A140TA82
ENST00000583700.5
I6L8A6
J3QL93
J3QLW6
ENST00000399725.6 [Q99708-3]
J3QRM0
F6Q6H0
ENST00000585177.1
J3QLH2
ENST00000579124.5
ENST00000577588.5
ENST00000360790.9
Q99708
ENST00000399722.6 [Q99708-1]
ENST00000581819.5