SLF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0032204Biological processregulation of telomere maintenance
GO_0006974Biological processDNA damage response
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0034184Biological processpositive regulation of maintenance of mitotic sister chromatid cohesion
GO_0140588Biological processchromatin looping
GO_1990166Biological processprotein localization to site of double-strand break
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0042405Cellular componentnuclear inclusion body
GO_0000786Cellular componentnucleosome
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0030915Cellular componentSmc5-Smc6 complex
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLF1
Protein nameSMC5-SMC6 complex localization factor 1
Ankyrin repeat domain 32
SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1)
SynonymsANKRD32
hCG_2016110
BRCTD1
DescriptionFUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance . The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks . Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions . .

AccessionsENST00000466957.1
Q9BQI6
ENST00000265140.10 [Q9BQI6-1]
ENST00000508130.5 [Q9BQI6-2]
H0YBU1
D6RED9
ENST00000504099.5
I6L9F1