Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 9 studies | 45% ± 25% | |
endothelial cell | 8 studies | 21% ± 7% | |
CD8-positive, alpha-beta T cell | 7 studies | 20% ± 4% | |
GABAergic neuron | 6 studies | 44% ± 21% | |
effector memory CD8-positive, alpha-beta T cell | 5 studies | 20% ± 3% | |
endothelial cell of lymphatic vessel | 5 studies | 19% ± 3% | |
interneuron | 5 studies | 42% ± 21% | |
CD8-positive, alpha-beta memory T cell | 4 studies | 20% ± 3% | |
lymphocyte | 4 studies | 22% ± 9% | |
T cell | 3 studies | 19% ± 1% | |
neuron | 3 studies | 27% ± 1% | |
epithelial cell | 3 studies | 20% ± 1% | |
CD4-positive, alpha-beta T cell | 3 studies | 24% ± 4% | |
ciliated cell | 3 studies | 26% ± 2% | |
astrocyte | 3 studies | 31% ± 15% | |
gamma-delta T cell | 3 studies | 24% ± 5% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 8 studies | 37% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 271.51 | 1439 / 1445 | 100% | 4.76 | 183 / 183 |
breast | 100% | 386.93 | 459 / 459 | 99% | 6.15 | 1112 / 1118 |
uterus | 100% | 405.42 | 170 / 170 | 99% | 7.56 | 455 / 459 |
lung | 99% | 383.72 | 574 / 578 | 100% | 5.39 | 1152 / 1155 |
brain | 99% | 873.86 | 2614 / 2642 | 100% | 4.21 | 702 / 705 |
thymus | 100% | 355.19 | 650 / 653 | 99% | 3.28 | 596 / 605 |
bladder | 100% | 277.24 | 21 / 21 | 98% | 4.04 | 494 / 504 |
prostate | 99% | 304.15 | 243 / 245 | 98% | 3.50 | 493 / 502 |
intestine | 100% | 337.72 | 964 / 966 | 97% | 3.61 | 510 / 527 |
adrenal gland | 98% | 315.36 | 253 / 258 | 97% | 4.41 | 223 / 230 |
pancreas | 97% | 224.16 | 317 / 328 | 98% | 2.83 | 174 / 178 |
stomach | 97% | 230.75 | 349 / 359 | 97% | 3.71 | 277 / 286 |
ovary | 100% | 401.23 | 180 / 180 | 94% | 2.43 | 403 / 430 |
skin | 100% | 464.31 | 1801 / 1809 | 93% | 4.67 | 441 / 472 |
kidney | 98% | 238.33 | 87 / 89 | 91% | 3.61 | 824 / 901 |
liver | 85% | 145.48 | 191 / 226 | 70% | 1.55 | 283 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 5.52 | 29 / 29 |
spleen | 100% | 590.61 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 7.82 | 45 / 45 |
adipose | 100% | 361.86 | 1201 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 97% | 231.52 | 1295 / 1335 | 0% | 0 | 0 / 0 |
heart | 93% | 318.70 | 803 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 89% | 568.19 | 830 / 929 | 0% | 0 | 0 / 0 |
muscle | 88% | 167.06 | 710 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 59% | 1.40 | 47 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0016925 | Biological process | protein sumoylation |
GO_0032204 | Biological process | regulation of telomere maintenance |
GO_0006974 | Biological process | DNA damage response |
GO_0031334 | Biological process | positive regulation of protein-containing complex assembly |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0034184 | Biological process | positive regulation of maintenance of mitotic sister chromatid cohesion |
GO_0140588 | Biological process | chromatin looping |
GO_1990166 | Biological process | protein localization to site of double-strand break |
GO_2000781 | Biological process | positive regulation of double-strand break repair |
GO_0042405 | Cellular component | nuclear inclusion body |
GO_0000786 | Cellular component | nucleosome |
GO_0005813 | Cellular component | centrosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0030915 | Cellular component | Smc5-Smc6 complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SLF1 |
Protein name | SMC5-SMC6 complex localization factor 1 Ankyrin repeat domain 32 SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) |
Synonyms | ANKRD32 hCG_2016110 BRCTD1 |
Description | FUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance . The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks . Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions . . |
Accessions | ENST00000466957.1 Q9BQI6 ENST00000265140.10 [Q9BQI6-1] ENST00000508130.5 [Q9BQI6-2] H0YBU1 D6RED9 ENST00000504099.5 I6L9F1 |