POLL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POLL at tissue level.

III. Associated gene sets

GO_0006289Biological processnucleotide-excision repair
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006287Biological processbase-excision repair, gap-filling
GO_0071897Biological processDNA biosynthetic process
GO_0016446Biological processsomatic hypermutation of immunoglobulin genes
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006260Biological processDNA replication
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0051575Molecular function5'-deoxyribose-5-phosphate lyase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePOLL
Protein nameDNA polymerase (EC 2.7.7.7)
DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa)
DNA polymerase lambda
SynonymshCG_23002
DescriptionFUNCTION: DNA polymerase that functions in several pathways of DNA repair . Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA . Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination . Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities . Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity . .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. .

AccessionsENST00000430045.1
ENST00000339310.7
ENST00000370168.7
Q9HBN3
Q5ZEY6
Q5JQP8
ENST00000413344.5
Q5JQP0
ENST00000370172.5
ENST00000415897.5
Q5JQN9
ENST00000429502.1
ENST00000370162.8 [Q9UGP5-1]
ENST00000628479.2 [Q9UGP5-2]
Q5JQP2
Q9UGP5
ENST00000299206.8 [Q9UGP5-1]
ENST00000370169.5 [Q9UGP5-1]
ENST00000426919.5
Q5ZEY5
Q5JQP7
Q5JQP1
Q5JQP4
ENST00000454524.1
Q5JQP3