INIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006974Biological processDNA damage response
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0006281Biological processDNA repair
GO_0010212Biological processresponse to ionizing radiation
GO_0070876Cellular componentSOSS complex
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameINIP
Protein nameSOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) (hSSBIP1)
SOSS complex subunit C (SOSS-C) (SSB-interacting protein 1) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (Single-stranded DNA-binding protein-interacting protein 1)
INTS3 and NABP interacting protein
SynonymsHSPC291
HSPC043
C9orf80
SSBIP1
DescriptionFUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. .

FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs). .

AccessionsQ5VWJ6
Q9NRY2
ENST00000374236.5
X6R8P6
ENST00000374242.9 [Q9NRY2-1]
ENST00000374234.1