EPC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	33% ± 15%	Explore
B cell	38 studies	36% ± 14%	Explore
natural killer cell	38 studies	37% ± 12%	Explore
CD8-positive, alpha-beta T cell	33 studies	35% ± 13%	Explore
CD4-positive, alpha-beta T cell	31 studies	39% ± 14%	Explore
T cell	29 studies	34% ± 12%	Explore
fibroblast	28 studies	30% ± 10%	Explore
smooth muscle cell	27 studies	27% ± 8%	Explore
regulatory T cell	27 studies	45% ± 16%	Explore
pericyte	25 studies	28% ± 11%	Explore
macrophage	23 studies	28% ± 14%	Explore
mast cell	20 studies	26% ± 8%	Explore
mature NK T cell	20 studies	37% ± 11%	Explore
memory B cell	20 studies	41% ± 12%	Explore
naive B cell	20 studies	39% ± 11%	Explore
astrocyte	20 studies	40% ± 17%	Explore
non-classical monocyte	18 studies	29% ± 15%	Explore
plasmacytoid dendritic cell	18 studies	39% ± 16%	Explore
gamma-delta T cell	17 studies	41% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	40% ± 12%	Explore
classical monocyte	17 studies	27% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	44% ± 13%	Explore
mucosal invariant T cell	16 studies	42% ± 14%	Explore
oligodendrocyte precursor cell	16 studies	39% ± 19%	Explore
conventional dendritic cell	15 studies	29% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	47% ± 14%	Explore
microglial cell	15 studies	39% ± 13%	Explore
endothelial cell of lymphatic vessel	14 studies	30% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	40% ± 12%	Explore
oligodendrocyte	14 studies	35% ± 14%	Explore
capillary endothelial cell	13 studies	24% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	40% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	43% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	44% ± 14%	Explore
basal cell	12 studies	28% ± 14%	Explore
monocyte	12 studies	26% ± 9%	Explore
glutamatergic neuron	12 studies	48% ± 24%	Explore
connective tissue cell	12 studies	26% ± 8%	Explore
dendritic cell	12 studies	44% ± 19%	Explore
ciliated cell	11 studies	28% ± 10%	Explore
myofibroblast cell	11 studies	31% ± 10%	Explore
epithelial cell	11 studies	37% ± 19%	Explore
GABAergic neuron	10 studies	51% ± 22%	Explore
endothelial cell of artery	10 studies	18% ± 3%	Explore
endothelial cell of vascular tree	10 studies	24% ± 13%	Explore
myeloid cell	10 studies	29% ± 9%	Explore
vein endothelial cell	10 studies	25% ± 13%	Explore
adipocyte	10 studies	44% ± 11%	Explore
plasma cell	9 studies	31% ± 12%	Explore
leukocyte	9 studies	36% ± 12%	Explore
neuron	9 studies	50% ± 20%	Explore
type I pneumocyte	9 studies	27% ± 7%	Explore
innate lymphoid cell	8 studies	35% ± 14%	Explore
plasmablast	8 studies	48% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	32% ± 8%	Explore
interneuron	7 studies	55% ± 17%	Explore
hematopoietic stem cell	7 studies	30% ± 11%	Explore
type II pneumocyte	7 studies	28% ± 7%	Explore
T follicular helper cell	7 studies	52% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	37% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	36% ± 13%	Explore
progenitor cell	6 studies	31% ± 10%	Explore
abnormal cell	6 studies	37% ± 18%	Explore
lymphocyte	6 studies	40% ± 16%	Explore
precursor B cell	6 studies	51% ± 11%	Explore
club cell	6 studies	27% ± 9%	Explore
amacrine cell	6 studies	42% ± 6%	Explore
retina horizontal cell	6 studies	40% ± 11%	Explore
retinal cone cell	6 studies	32% ± 7%	Explore
retinal rod cell	6 studies	29% ± 7%	Explore
mesothelial cell	6 studies	29% ± 13%	Explore
Mueller cell	6 studies	36% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	43% ± 18%	Explore
exhausted T cell	5 studies	44% ± 14%	Explore
retinal bipolar neuron	5 studies	35% ± 7%	Explore
pro-B cell	5 studies	40% ± 8%	Explore
immature B cell	5 studies	53% ± 4%	Explore
cardiac muscle cell	5 studies	44% ± 9%	Explore
respiratory goblet cell	5 studies	28% ± 12%	Explore
goblet cell	5 studies	32% ± 22%	Explore
CD4-positive helper T cell	4 studies	37% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	35% ± 10%	Explore
hematopoietic precursor cell	4 studies	39% ± 17%	Explore
secretory cell	4 studies	24% ± 6%	Explore
pancreatic A cell	4 studies	29% ± 6%	Explore
mononuclear phagocyte	4 studies	29% ± 6%	Explore
glial cell	4 studies	35% ± 7%	Explore
granule cell	4 studies	43% ± 9%	Explore
retinal pigment epithelial cell	4 studies	35% ± 18%	Explore
retinal ganglion cell	4 studies	31% ± 11%	Explore
hepatocyte	4 studies	46% ± 13%	Explore
enteroendocrine cell	4 studies	26% ± 8%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	32% ± 14%	Explore
platelet	3 studies	18% ± 2%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	46% ± 3%	Explore
neural crest cell	3 studies	21% ± 1%	Explore
GABAergic interneuron	3 studies	37% ± 10%	Explore
GABAergic amacrine cell	3 studies	46% ± 8%	Explore
OFF-bipolar cell	3 studies	36% ± 8%	Explore
ON-bipolar cell	3 studies	40% ± 8%	Explore
glycinergic amacrine cell	3 studies	43% ± 10%	Explore
rod bipolar cell	3 studies	40% ± 7%	Explore
germinal center B cell	3 studies	33% ± 13%	Explore
intermediate monocyte	3 studies	49% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	22% ± 5%	Explore
muscle cell	3 studies	38% ± 25%	Explore
neural progenitor cell	3 studies	44% ± 7%	Explore
ependymal cell	3 studies	46% ± 17%	Explore
granulocyte	3 studies	31% ± 7%	Explore
adventitial cell	3 studies	21% ± 3%	Explore
alveolar macrophage	3 studies	33% ± 9%	Explore
chondrocyte	3 studies	29% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	53% ± 9%	Explore
Schwann cell	3 studies	35% ± 12%	Explore
brush cell	3 studies	27% ± 7%	Explore
T-helper 17 cell	3 studies	34% ± 7%	Explore
T-helper 1 cell	3 studies	42% ± 18%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	47% ± 15%	Explore
double negative thymocyte	3 studies	55% ± 10%	Explore
double-positive, alpha-beta thymocyte	3 studies	60% ± 8%	Explore
myoepithelial cell	3 studies	34% ± 12%	Explore
mural cell	3 studies	46% ± 8%	Explore
erythrocyte	3 studies	35% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	39% ± 13%	Explore
brain	18 studies	42% ± 19%	Explore
lung	17 studies	25% ± 7%	Explore
eye	9 studies	34% ± 12%	Explore
intestine	8 studies	23% ± 8%	Explore
kidney	5 studies	27% ± 8%	Explore
heart	5 studies	33% ± 8%	Explore
lymph node	5 studies	31% ± 13%	Explore
liver	5 studies	34% ± 11%	Explore
pancreas	4 studies	25% ± 5%	Explore
bone marrow	4 studies	30% ± 10%	Explore
uterus	4 studies	24% ± 9%	Explore
breast	4 studies	23% ± 3%	Explore
adipose	4 studies	40% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	2684.62	245 / 245	100%	8.97	502 / 502
esophagus	100%	2020.19	1444 / 1445	100%	6.90	183 / 183
breast	100%	2622.23	459 / 459	100%	10.59	1117 / 1118
uterus	100%	3329.85	170 / 170	100%	6.89	457 / 459
ovary	100%	2926.39	180 / 180	100%	8.30	428 / 430
thymus	100%	2749.95	653 / 653	100%	10.20	602 / 605
lung	100%	2016.27	577 / 578	100%	6.97	1151 / 1155
brain	99%	1570.18	2628 / 2642	100%	10.39	705 / 705
intestine	100%	2511.35	966 / 966	99%	6.53	524 / 527
stomach	100%	1538.63	359 / 359	99%	7.01	284 / 286
bladder	100%	2767.62	21 / 21	99%	6.16	498 / 504
pancreas	100%	1115.20	327 / 328	99%	7.10	176 / 178
adrenal gland	100%	1360.13	258 / 258	96%	5.30	221 / 230
kidney	100%	1372.87	89 / 89	93%	6.88	841 / 901
skin	100%	2085.82	1809 / 1809	92%	5.50	435 / 472
liver	100%	976.36	226 / 226	92%	4.42	373 / 406
adipose	100%	2464.20	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2209.62	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	6.62	29 / 29
spleen	100%	2470.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	6.28	45 / 45
ureter	0%	0	0 / 0	100%	3.34	1 / 1
muscle	100%	2038.06	802 / 803	0%	0	0 / 0
heart	99%	1201.66	849 / 861	0%	0	0 / 0
peripheral blood	94%	1477.80	871 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	85%	4.59	68 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045814	Biological process	negative regulation of gene expression, epigenetic
GO_2000779	Biological process	regulation of double-strand break repair
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0006351	Biological process	DNA-templated transcription
GO_0042981	Biological process	regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_1905168	Biological process	positive regulation of double-strand break repair via homologous recombination
GO_0035092	Biological process	sperm DNA condensation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0007286	Biological process	spermatid development
GO_0051726	Biological process	regulation of cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0000786	Cellular component	nucleosome
GO_0005654	Cellular component	nucleoplasm
GO_0035267	Cellular component	NuA4 histone acetyltransferase complex
GO_0032777	Cellular component	piccolo histone acetyltransferase complex
GO_0016604	Cellular component	nuclear body
GO_0005737	Cellular component	cytoplasm
GO_0031965	Cellular component	nuclear membrane
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0140767	Molecular function	enzyme-substrate adaptor activity
GO_0140463	Molecular function	chromatin-protein adaptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EPC1
Protein name	Enhancer of polycomb homolog 1 Enhancer of polycomb homolog
Synonyms
Description	FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A . The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) . The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex . .
Accessions	ENST00000469059.2 ENST00000263062.8 [Q9H2F5-1] Q9H2F5 ENST00000667706.1 ENST00000319778.11 [Q9H2F5-2] A0A590UJ89 A0A590UJ87 ENST00000480402.1 ENST00000375110.6 [Q9H2F5-3] A0A590UJN0

EPC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review