SIRT6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIRT6 at tissue level.

III. Associated gene sets

GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_2000773Biological processnegative regulation of cellular senescence
GO_0009411Biological processresponse to UV
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_1905555Biological processpositive regulation of blood vessel branching
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0050708Biological processregulation of protein secretion
GO_0031508Biological processpericentric heterochromatin formation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0120187Biological processpositive regulation of protein localization to chromatin
GO_0006302Biological processdouble-strand break repair
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0042308Biological processnegative regulation of protein import into nucleus
GO_0043687Biological processpost-translational protein modification
GO_0042752Biological processregulation of circadian rhythm
GO_0045820Biological processnegative regulation of glycolytic process
GO_0032206Biological processpositive regulation of telomere maintenance
GO_1990166Biological processprotein localization to site of double-strand break
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0042181Biological processketone biosynthetic process
GO_0006476Biological processprotein deacetylation
GO_0019216Biological processregulation of lipid metabolic process
GO_0031648Biological processprotein destabilization
GO_0032024Biological processpositive regulation of insulin secretion
GO_0120186Biological processnegative regulation of protein localization to chromatin
GO_0031509Biological processsubtelomeric heterochromatin formation
GO_1902732Biological processpositive regulation of chondrocyte proliferation
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0051697Biological processprotein delipidation
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0055007Biological processcardiac muscle cell differentiation
GO_0008340Biological processdetermination of adult lifespan
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_0010526Biological processretrotransposon silencing
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0050994Biological processregulation of lipid catabolic process
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006284Biological processbase-excision repair
GO_2000738Biological processpositive regulation of stem cell differentiation
GO_0042593Biological processglucose homeostasis
GO_0046325Biological processnegative regulation of glucose import
GO_0005721Cellular componentpericentric heterochromatin
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0035861Cellular componentsite of double-strand break
GO_0090734Cellular componentsite of DNA damage
GO_0005783Cellular componentendoplasmic reticulum
GO_0000785Cellular componentchromatin
GO_0099115Cellular componentchromosome, subtelomeric region
GO_0140804Molecular functionNAD+- protein-lysine ADP-ribosyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0097372Molecular functionNAD-dependent histone H3K18 deacetylase activity
GO_0031490Molecular functionchromatin DNA binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0046969Molecular functionNAD-dependent histone H3K9 deacetylase activity
GO_0140612Molecular functionDNA damage sensor activity
GO_0140765Molecular functionNAD-dependent histone H3K56 deacetylase activity
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0106274Molecular functionNAD+-protein-arginine ADP-ribosyltransferase activity
GO_0017136Molecular functionNAD-dependent histone deacetylase activity
GO_0070403Molecular functionNAD+ binding
GO_0034979Molecular functionNAD-dependent protein lysine deacetylase activity
GO_0140773Molecular functionNAD-dependent protein demyristoylase activity
GO_0031491Molecular functionnucleosome binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_1904841Molecular functionTORC2 complex binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0140774Molecular functionNAD-dependent protein depalmitoylase activity

IV. Literature review

[source]
Gene nameSIRT6
Protein nameNAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
protein acetyllysine N-acetyltransferase (EC 2.3.1.286)
Sirtuin 6
SynonymshCG_2004101
SIR2L6
DescriptionFUNCTION: NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging . Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context . Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B . Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (By similarity). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac . SIRT6 participation to DSB repair is probably involved in extension of life span (By similarity). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 . Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence . Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage . Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac . Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism . Inhibits glycolysis via histone deacetylase activity and by acting as a corepressor of the transcription factor HIF1A, thereby controlling the expression of multiple glycolytic genes (By similarity). Has tumor suppressor activity by repressing glycolysis, thereby inhibiting the Warburg effect . Also regulates glycolysis and tumorigenesis by mediating deacetylation and nuclear export of non-histone proteins, such as isoform M2 of PKM (PKM2) . Acts as a negative regulator of gluconeogenesis by mediating deacetylation of non-histone proteins, such as FOXO1 and KAT2A/GCN5 . Promotes beta-oxidation of fatty acids during fasting by catalyzing deacetylation of NCOA2, inducing coactivation of PPARA (By similarity). Acts as a regulator of lipid catabolism in brown adipocytes, both by catalyzing deacetylation of histones and non-histone proteins, such as FOXO1 (By similarity). Also acts as a regulator of circadian rhythms, both by regulating expression of clock-controlled genes involved in lipid and carbohydrate metabolism, and by catalyzing deacetylation of PER2 (By similarity). The defatty-acylase activity is specifically involved in regulation of protein secretion . Has high activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as RRAS2 and TNF, thereby regulating their secretion . Also acts as a mono-ADP-ribosyltransferase by mediating mono-ADP-ribosylation of PARP1, TRIM28/KAP1 or SMARCC2/BAF170 . Mono-ADP-ribosyltransferase activity is involved in DNA repair, cellular senescence, repression of LINE-1 retrotransposon elements and regulation of transcription . .

AccessionsM0QXA0
ENST00000601488.5
M0R1F6
ENST00000337491.7 [Q8N6T7-1]
ENST00000600938.5
ENST00000594279.5
ENST00000599365.5
M0R1N9
ENST00000305232.10 [Q8N6T7-2]
M0R0B2
ENST00000601571.1
Q8N6T7
ENST00000597896.5
M0QZ09