Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 2093.83 | 578 / 578 | 96% | 20.75 | 1105 / 1155 |
| breast | 93% | 472.34 | 429 / 459 | 95% | 17.26 | 1058 / 1118 |
| prostate | 90% | 464.99 | 221 / 245 | 86% | 8.30 | 430 / 502 |
| bladder | 100% | 556.19 | 21 / 21 | 76% | 14.33 | 381 / 504 |
| liver | 94% | 385.06 | 213 / 226 | 81% | 10.15 | 327 / 406 |
| intestine | 92% | 914.58 | 891 / 966 | 82% | 13.39 | 431 / 527 |
| stomach | 81% | 363.96 | 292 / 359 | 85% | 17.86 | 243 / 286 |
| kidney | 72% | 388.71 | 64 / 89 | 92% | 20.96 | 829 / 901 |
| uterus | 68% | 233.36 | 115 / 170 | 90% | 14.40 | 413 / 459 |
| esophagus | 71% | 285.09 | 1028 / 1445 | 86% | 12.52 | 157 / 183 |
| thymus | 74% | 373.26 | 484 / 653 | 82% | 29.16 | 496 / 605 |
| brain | 56% | 237.09 | 1481 / 2642 | 99% | 26.59 | 700 / 705 |
| adrenal gland | 92% | 512.91 | 237 / 258 | 57% | 5.44 | 131 / 230 |
| skin | 42% | 126.73 | 753 / 1809 | 90% | 27.05 | 427 / 472 |
| ovary | 32% | 110.88 | 58 / 180 | 91% | 14.74 | 390 / 430 |
| pancreas | 23% | 84.80 | 75 / 328 | 93% | 22.58 | 166 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 301.97 | 29 / 29 |
| peripheral blood | 100% | 19684.86 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 8356.65 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 891.92 | 1192 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 26.86 | 42 / 45 |
| blood vessel | 67% | 402.21 | 901 / 1335 | 0% | 0 | 0 / 0 |
| heart | 47% | 171.70 | 407 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 44% | 5.61 | 35 / 80 |
| muscle | 6% | 14.63 | 46 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008544 | Biological process | epidermis development |
| GO_0030048 | Biological process | actin filament-based movement |
| GO_0008064 | Biological process | regulation of actin polymerization or depolymerization |
| GO_0030041 | Biological process | actin filament polymerization |
| GO_0007596 | Biological process | blood coagulation |
| GO_0008154 | Biological process | actin polymerization or depolymerization |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0071346 | Biological process | cellular response to type II interferon |
| GO_0006955 | Biological process | immune response |
| GO_0010591 | Biological process | regulation of lamellipodium assembly |
| GO_2001032 | Biological process | regulation of double-strand break repair via nonhomologous end joining |
| GO_0016197 | Biological process | endosomal transport |
| GO_0051492 | Biological process | regulation of stress fiber assembly |
| GO_0002625 | Biological process | regulation of T cell antigen processing and presentation |
| GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
| GO_0032488 | Biological process | Cdc42 protein signal transduction |
| GO_0007266 | Biological process | Rho protein signal transduction |
| GO_0042110 | Biological process | T cell activation |
| GO_2000146 | Biological process | negative regulation of cell motility |
| GO_0051497 | Biological process | negative regulation of stress fiber assembly |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0006952 | Biological process | defense response |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0012506 | Cellular component | vesicle membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005884 | Cellular component | actin filament |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0045335 | Cellular component | phagocytic vesicle |
| GO_0035861 | Cellular component | site of double-strand break |
| GO_0005634 | Cellular component | nucleus |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0030695 | Molecular function | GTPase regulator activity |
| GO_0043274 | Molecular function | phospholipase binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| GO_0017124 | Molecular function | SH3 domain binding |
| Gene name | WAS |
| Protein name | WASP actin nucleation promoting factor Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) |
| Synonyms | IMD2 |
| Description | FUNCTION: Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex . Important for efficient actin polymerization . Possible regulator of lymphocyte and platelet function . Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria . In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . . |
| Accessions | C9J3B7 A0A8V8TNH9 ENST00000450772.5 ENST00000698625.1 A0A8V8TM35 ENST00000376701.5 ENST00000698635.1 P42768 ENST00000698626.1 |
