Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 4 studies | 22% ± 3% | |
| plasmacytoid dendritic cell | 4 studies | 23% ± 4% | |
| hematopoietic precursor cell | 3 studies | 21% ± 6% | |
| endothelial cell | 3 studies | 27% ± 8% | |
| epithelial cell | 3 studies | 23% ± 5% | |
| hepatocyte | 3 studies | 42% ± 26% | |
| astrocyte | 3 studies | 22% ± 6% | |
| dendritic cell | 3 studies | 25% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1749.64 | 1445 / 1445 | 14% | 0.18 | 25 / 183 |
| lung | 100% | 2940.56 | 578 / 578 | 8% | 0.14 | 88 / 1155 |
| stomach | 100% | 1937.86 | 359 / 359 | 5% | 0.08 | 13 / 286 |
| liver | 100% | 2704.73 | 226 / 226 | 4% | 0.06 | 16 / 406 |
| skin | 100% | 2755.11 | 1808 / 1809 | 3% | 0.04 | 15 / 472 |
| bladder | 100% | 2098.52 | 21 / 21 | 3% | 0.07 | 14 / 504 |
| intestine | 100% | 2438.35 | 966 / 966 | 3% | 0.05 | 14 / 527 |
| breast | 100% | 2185.14 | 459 / 459 | 3% | 0.07 | 29 / 1118 |
| uterus | 100% | 2954.64 | 170 / 170 | 2% | 0.03 | 9 / 459 |
| brain | 100% | 2455.43 | 2641 / 2642 | 2% | 0.03 | 14 / 705 |
| kidney | 100% | 1999.56 | 89 / 89 | 1% | 0.03 | 12 / 901 |
| pancreas | 99% | 1174.53 | 326 / 328 | 2% | 0.03 | 3 / 178 |
| prostate | 100% | 2712.09 | 245 / 245 | 1% | 0.02 | 5 / 502 |
| ovary | 100% | 1667.53 | 180 / 180 | 0% | 0.00 | 1 / 430 |
| adipose | 100% | 2100.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 100% | 2174.29 | 258 / 258 | 0% | 0 | 0 / 230 |
| spleen | 100% | 4197.39 | 241 / 241 | 0% | 0 | 0 / 0 |
| thymus | 100% | 1907.10 | 652 / 653 | 0% | 0 | 0 / 605 |
| blood vessel | 100% | 3246.12 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1460.81 | 799 / 803 | 0% | 0 | 0 / 0 |
| heart | 94% | 1066.44 | 812 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 90% | 1784.62 | 840 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032508 | Biological process | DNA duplex unwinding |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0006974 | Biological process | DNA damage response |
| GO_0006281 | Biological process | DNA repair |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0035861 | Cellular component | site of double-strand break |
| GO_0005634 | Cellular component | nucleus |
| GO_0031491 | Molecular function | nucleosome binding |
| GO_0160004 | Molecular function | poly-ADP-D-ribose modification-dependent protein binding |
| GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0003678 | Molecular function | DNA helicase activity |
| GO_0140566 | Molecular function | histone reader activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| GO_0000166 | Molecular function | nucleotide binding |
| Gene name | CHD1L |
| Protein name | Chromodomain helicase DNA binding protein 1-like isoform A Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) Chromodomain helicase DNA binding protein 1 like |
| Synonyms | ALC1 |
| Description | FUNCTION: ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage . Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage . Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair . Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner . Chromatin remodeling activity promotes PARP2 removal from chromatin . . |
| Accessions | A0A494C0Q0 ENST00000652587.1 ENST00000467213.5 ENST00000431239.6 ENST00000650714.1 A0A494C1P7 ENST00000652494.1 A0A087WWW4 ENST00000652357.1 A0A494C179 ENST00000652278.1 ENST00000651207.1 ENST00000622533.4 ENST00000651070.1 X5D2E5 ENST00000651410.1 A0A494C1S1 A0A494C0J6 A0A494C111 A0A494C1H0 A0A0A0MSH9 ENST00000369259.4 [Q86WJ1-3] A0A494C0M4 ENST00000652616.1 A0A494C1I3 ENST00000652161.1 ENST00000652346.1 ENST00000650721.1 Q86WJ1 A0A494C0B8 ENST00000651420.1 A0A0A0MRH8 ENST00000651231.1 ENST00000369258.8 [Q86WJ1-1] A0A087WTM4 ENST00000488864.5 ENST00000651820.1 ENST00000652188.1 ENST00000651226.1 A0A087WZM7 ENST00000651407.1 ENST00000651510.1 ENST00000650828.1 ENST00000361293.10 ENST00000652486.1 A0A494C1F7 A0A494C1H1 ENST00000651206.1 A0A494C0F0 A0A494C1F3 |
