PHF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0005813Cellular componentcentrosome
GO_0035098Cellular componentESC/E(Z) complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0003677Molecular functionDNA binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_1990226Molecular functionhistone methyltransferase binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene namePHF1
Protein namePHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)
PHD finger protein 1
SynonymsPCL1
DescriptionFUNCTION: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci . According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 . Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. .

AccessionsA2AB23
A0A087WVG4
A2AB25
ENST00000454914.6
ENST00000487667.5
ENST00000495509.6
ENST00000423868.1
ENST00000374512.7 [O43189-2]
ENST00000427826.1
ENST00000459809.5
A0A140TA01
A2AB22
A0A140TA07
ENST00000427004.5
ENST00000428274.5
E9PQZ5
A0A0G2JIJ9
E9PQT8
ENST00000419154.5
ENST00000495185.5
ENST00000421466.5
O43189
ENST00000427869.6
A0A140T9U3
ENST00000374516.8 [O43189-1]
ENST00000447305.5
ENST00000475137.5