Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 10 studies | 19% ± 3% | |
ciliated cell | 8 studies | 22% ± 7% | |
B cell | 8 studies | 18% ± 3% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 18% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 6 studies | 20% ± 3% | |
epithelial cell | 6 studies | 27% ± 10% | |
naive B cell | 5 studies | 18% ± 3% | |
endothelial cell | 5 studies | 20% ± 5% | |
CD8-positive, alpha-beta T cell | 4 studies | 20% ± 3% | |
classical monocyte | 4 studies | 22% ± 7% | |
plasma cell | 4 studies | 29% ± 9% | |
gamma-delta T cell | 4 studies | 23% ± 9% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
non-classical monocyte | 3 studies | 27% ± 6% | |
plasmablast | 3 studies | 35% ± 14% | |
regulatory T cell | 3 studies | 18% ± 2% | |
dendritic cell | 3 studies | 27% ± 8% | |
basal cell | 3 studies | 24% ± 5% | |
transit amplifying cell | 3 studies | 25% ± 4% | |
goblet cell | 3 studies | 19% ± 1% | |
innate lymphoid cell | 3 studies | 17% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 4460.28 | 258 / 258 | 100% | 39.35 | 230 / 230 |
esophagus | 100% | 1629.60 | 1445 / 1445 | 100% | 23.91 | 183 / 183 |
pancreas | 100% | 1652.34 | 328 / 328 | 100% | 30.17 | 178 / 178 |
thymus | 100% | 3504.32 | 653 / 653 | 100% | 32.97 | 605 / 605 |
uterus | 100% | 2528.69 | 170 / 170 | 100% | 34.32 | 458 / 459 |
ovary | 100% | 2309.32 | 180 / 180 | 100% | 26.84 | 429 / 430 |
liver | 100% | 1299.62 | 226 / 226 | 100% | 18.47 | 405 / 406 |
stomach | 100% | 1860.77 | 359 / 359 | 100% | 24.07 | 285 / 286 |
intestine | 100% | 2007.88 | 966 / 966 | 100% | 26.69 | 525 / 527 |
prostate | 100% | 2935.00 | 245 / 245 | 100% | 39.59 | 500 / 502 |
lung | 100% | 2344.57 | 578 / 578 | 100% | 25.64 | 1150 / 1155 |
kidney | 100% | 2548.30 | 89 / 89 | 100% | 21.50 | 897 / 901 |
skin | 100% | 1593.58 | 1808 / 1809 | 100% | 31.71 | 470 / 472 |
bladder | 100% | 1893.95 | 21 / 21 | 99% | 33.79 | 501 / 504 |
breast | 100% | 2199.45 | 459 / 459 | 99% | 24.04 | 1107 / 1118 |
brain | 98% | 1115.28 | 2591 / 2642 | 100% | 16.68 | 702 / 705 |
adipose | 100% | 1860.17 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 31.51 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 34.69 | 29 / 29 |
spleen | 100% | 4032.56 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 32.48 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 26.48 | 1 / 1 |
blood vessel | 100% | 1564.98 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 1404.79 | 856 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 1937.98 | 921 / 929 | 0% | 0 | 0 / 0 |
muscle | 98% | 886.81 | 789 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051103 | Biological process | DNA ligation involved in DNA repair |
GO_2001034 | Biological process | positive regulation of double-strand break repair via nonhomologous end joining |
GO_0006303 | Biological process | double-strand break repair via nonhomologous end joining |
GO_0006281 | Biological process | DNA repair |
GO_1904355 | Biological process | positive regulation of telomere capping |
GO_0006287 | Biological process | base-excision repair, gap-filling |
GO_0009314 | Biological process | response to radiation |
GO_0006289 | Biological process | nucleotide-excision repair |
GO_0010836 | Biological process | negative regulation of protein ADP-ribosylation |
GO_0051973 | Biological process | positive regulation of telomerase activity |
GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
GO_0006979 | Biological process | response to oxidative stress |
GO_0006261 | Biological process | DNA-templated DNA replication |
GO_0005730 | Cellular component | nucleolus |
GO_0016020 | Cellular component | membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0017076 | Molecular function | purine nucleotide binding |
GO_0004519 | Molecular function | endonuclease activity |
GO_0003690 | Molecular function | double-stranded DNA binding |
GO_0046404 | Molecular function | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0046403 | Molecular function | polynucleotide 3'-phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0003684 | Molecular function | damaged DNA binding |
Gene name | PNKP |
Protein name | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] Bifunctional polynucleotide phosphatase/kinase Polynucleotide kinase 3'-phosphatase |
Synonyms | |
Description | FUNCTION: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways . Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone . . |
Accessions | ENST00000600910.5 A0A0D9SFU1 ENST00000593946.5 A0A1B0GVJ3 A0A1B0GW61 M0QYH2 A0A1B0GW17 ENST00000598020.3 A0A224APX3 ENST00000625216.2 A0A224AHB5 A0A0D9SEV0 A0A0D9SFL2 A0A1S5RA93 ENST00000627232.2 A0A1W2PP58 ENST00000631020.2 M0R097 M0QX49 M0R000 A0A1B0GU66 Q96T60 ENST00000600573.5 ENST00000640501.1 ENST00000597965.2 M0R3C8 ENST00000636840.1 ENST00000637897.1 ENST00000627317.1 ENST00000596014.5 [Q96T60-1] ENST00000596726.3 A0A0D9SFD6 ENST00000322344.8 [Q96T60-1] ENST00000599543.3 ENST00000636214.1 M0QYI1 ENST00000636994.1 |