PNKP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051103Biological processDNA ligation involved in DNA repair
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_1904355Biological processpositive regulation of telomere capping
GO_0006287Biological processbase-excision repair, gap-filling
GO_0009314Biological processresponse to radiation
GO_0006289Biological processnucleotide-excision repair
GO_0010836Biological processnegative regulation of protein ADP-ribosylation
GO_0051973Biological processpositive regulation of telomerase activity
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0006979Biological processresponse to oxidative stress
GO_0006261Biological processDNA-templated DNA replication
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0017076Molecular functionpurine nucleotide binding
GO_0004519Molecular functionendonuclease activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0046404Molecular functionATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO_0005524Molecular functionATP binding
GO_0046403Molecular functionpolynucleotide 3'-phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene namePNKP
Protein nameBifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]
Bifunctional polynucleotide phosphatase/kinase
Polynucleotide kinase 3'-phosphatase
Synonyms
DescriptionFUNCTION: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways . Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone . .

AccessionsENST00000600910.5
A0A0D9SFU1
ENST00000593946.5
A0A1B0GVJ3
A0A1B0GW61
M0QYH2
A0A1B0GW17
ENST00000598020.3
A0A224APX3
ENST00000625216.2
A0A224AHB5
A0A0D9SEV0
A0A0D9SFL2
A0A1S5RA93
ENST00000627232.2
A0A1W2PP58
ENST00000631020.2
M0R097
M0QX49
M0R000
A0A1B0GU66
Q96T60
ENST00000600573.5
ENST00000640501.1
ENST00000597965.2
M0R3C8
ENST00000636840.1
ENST00000637897.1
ENST00000627317.1
ENST00000596014.5 [Q96T60-1]
ENST00000596726.3
A0A0D9SFD6
ENST00000322344.8 [Q96T60-1]
ENST00000599543.3
ENST00000636214.1
M0QYI1
ENST00000636994.1