Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 14 studies | 41% ± 15% | |
endothelial cell | 13 studies | 23% ± 6% | |
oligodendrocyte precursor cell | 10 studies | 34% ± 13% | |
fibroblast | 9 studies | 22% ± 6% | |
astrocyte | 9 studies | 30% ± 13% | |
GABAergic neuron | 7 studies | 33% ± 19% | |
glutamatergic neuron | 7 studies | 38% ± 23% | |
microglial cell | 6 studies | 26% ± 8% | |
macrophage | 6 studies | 26% ± 6% | |
epithelial cell | 5 studies | 26% ± 8% | |
endothelial cell of lymphatic vessel | 5 studies | 25% ± 6% | |
neuron | 4 studies | 29% ± 16% | |
adipocyte | 4 studies | 18% ± 2% | |
lymphocyte | 4 studies | 18% ± 2% | |
interneuron | 4 studies | 38% ± 22% | |
myeloid cell | 3 studies | 24% ± 9% | |
basal cell | 3 studies | 21% ± 7% | |
monocyte | 3 studies | 17% ± 1% | |
transit amplifying cell | 3 studies | 29% ± 16% | |
smooth muscle cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 3145.19 | 2641 / 2642 | 100% | 22.88 | 705 / 705 |
esophagus | 100% | 2120.74 | 1444 / 1445 | 100% | 14.03 | 183 / 183 |
breast | 100% | 2467.39 | 459 / 459 | 100% | 20.01 | 1115 / 1118 |
prostate | 100% | 3152.31 | 245 / 245 | 100% | 11.15 | 500 / 502 |
uterus | 100% | 4354.36 | 170 / 170 | 100% | 15.89 | 457 / 459 |
bladder | 100% | 2591.38 | 21 / 21 | 99% | 10.89 | 501 / 504 |
lung | 100% | 2721.29 | 576 / 578 | 100% | 12.27 | 1152 / 1155 |
thymus | 100% | 2421.55 | 653 / 653 | 99% | 13.74 | 600 / 605 |
adrenal gland | 100% | 3808.03 | 258 / 258 | 99% | 17.28 | 227 / 230 |
intestine | 100% | 2682.66 | 966 / 966 | 98% | 9.46 | 515 / 527 |
pancreas | 99% | 1698.51 | 326 / 328 | 98% | 11.72 | 175 / 178 |
stomach | 99% | 1767.44 | 357 / 359 | 98% | 10.41 | 281 / 286 |
skin | 100% | 2614.00 | 1808 / 1809 | 97% | 17.31 | 458 / 472 |
kidney | 100% | 1892.35 | 89 / 89 | 96% | 12.42 | 868 / 901 |
ovary | 100% | 5839.52 | 180 / 180 | 95% | 8.49 | 408 / 430 |
liver | 100% | 1214.95 | 225 / 226 | 85% | 7.34 | 347 / 406 |
muscle | 100% | 2576.21 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4721.13 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 14.00 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.84 | 1 / 1 |
adipose | 100% | 2414.85 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1991.81 | 1329 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 1607.72 | 843 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 14.48 | 28 / 29 |
eye | 0% | 0 | 0 / 0 | 91% | 9.50 | 73 / 80 |
peripheral blood | 69% | 1135.87 | 641 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016925 | Biological process | protein sumoylation |
GO_0032204 | Biological process | regulation of telomere maintenance |
GO_0006974 | Biological process | DNA damage response |
GO_0031334 | Biological process | positive regulation of protein-containing complex assembly |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0034184 | Biological process | positive regulation of maintenance of mitotic sister chromatid cohesion |
GO_0140588 | Biological process | chromatin looping |
GO_1990166 | Biological process | protein localization to site of double-strand break |
GO_2000781 | Biological process | positive regulation of double-strand break repair |
GO_0005654 | Cellular component | nucleoplasm |
GO_0030915 | Cellular component | Smc5-Smc6 complex |
GO_0016605 | Cellular component | PML body |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0000785 | Cellular component | chromatin |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SLF2 |
Protein name | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) FAM178A protein SMC5-SMC6 complex localization factor 2 Alternative protein FAM178A |
Synonyms | FAM178A C10orf6 |
Description | FUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance . The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks . Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions . Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication . . |
Accessions | ENST00000370271.7 ENST00000238961.9 [Q8IX21-1] Q05BG6 A0A3B3IRS8 ENST00000370269.3 [Q8IX21-2] Q8WW40 Q8IX21 L8E8Q4 B1AL16 ENST00000649226.1 ENST00000609386.1 [Q8IX21-3] |