SLF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0032204Biological processregulation of telomere maintenance
GO_0006974Biological processDNA damage response
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0034184Biological processpositive regulation of maintenance of mitotic sister chromatid cohesion
GO_0140588Biological processchromatin looping
GO_1990166Biological processprotein localization to site of double-strand break
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0005654Cellular componentnucleoplasm
GO_0030915Cellular componentSmc5-Smc6 complex
GO_0016605Cellular componentPML body
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLF2
Protein nameSMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)
FAM178A protein
SMC5-SMC6 complex localization factor 2
Alternative protein FAM178A
SynonymsFAM178A
C10orf6
DescriptionFUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance . The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks . Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions . Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication . .

AccessionsENST00000370271.7
ENST00000238961.9 [Q8IX21-1]
Q05BG6
A0A3B3IRS8
ENST00000370269.3 [Q8IX21-2]
Q8WW40
Q8IX21
L8E8Q4
B1AL16
ENST00000649226.1
ENST00000609386.1 [Q8IX21-3]