Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 27% ± 13% | |
astrocyte | 11 studies | 29% ± 14% | |
oligodendrocyte | 11 studies | 27% ± 11% | |
oligodendrocyte precursor cell | 10 studies | 33% ± 14% | |
glutamatergic neuron | 9 studies | 42% ± 26% | |
GABAergic neuron | 7 studies | 45% ± 18% | |
interneuron | 6 studies | 43% ± 20% | |
macrophage | 6 studies | 25% ± 6% | |
microglial cell | 6 studies | 26% ± 7% | |
fibroblast | 6 studies | 21% ± 6% | |
neuron | 5 studies | 34% ± 12% | |
epithelial cell | 5 studies | 28% ± 10% | |
adipocyte | 5 studies | 21% ± 4% | |
granule cell | 4 studies | 24% ± 5% | |
endothelial cell of lymphatic vessel | 4 studies | 21% ± 2% | |
GABAergic interneuron | 3 studies | 25% ± 9% | |
progenitor cell | 3 studies | 26% ± 5% | |
cardiac muscle cell | 3 studies | 18% ± 1% | |
ciliated cell | 3 studies | 25% ± 4% | |
amacrine cell | 3 studies | 26% ± 3% | |
basal cell | 3 studies | 27% ± 15% | |
mast cell | 3 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1882.94 | 1445 / 1445 | 100% | 25.31 | 183 / 183 |
brain | 100% | 1739.49 | 2632 / 2642 | 100% | 27.75 | 702 / 705 |
lung | 99% | 1691.60 | 572 / 578 | 100% | 20.68 | 1153 / 1155 |
breast | 100% | 2285.22 | 459 / 459 | 99% | 25.89 | 1104 / 1118 |
ovary | 100% | 2732.38 | 180 / 180 | 98% | 15.85 | 423 / 430 |
thymus | 100% | 2570.88 | 653 / 653 | 98% | 19.61 | 595 / 605 |
stomach | 100% | 1609.20 | 359 / 359 | 98% | 19.96 | 281 / 286 |
bladder | 100% | 2131.29 | 21 / 21 | 98% | 17.92 | 494 / 504 |
prostate | 100% | 2098.18 | 245 / 245 | 98% | 18.13 | 490 / 502 |
intestine | 100% | 1949.19 | 966 / 966 | 98% | 17.99 | 514 / 527 |
pancreas | 100% | 1225.09 | 327 / 328 | 98% | 14.52 | 174 / 178 |
kidney | 100% | 1565.11 | 89 / 89 | 97% | 18.12 | 874 / 901 |
uterus | 100% | 2665.93 | 170 / 170 | 97% | 17.51 | 445 / 459 |
adrenal gland | 100% | 2075.48 | 258 / 258 | 96% | 16.35 | 220 / 230 |
skin | 100% | 2727.48 | 1809 / 1809 | 93% | 25.18 | 441 / 472 |
liver | 100% | 1079.04 | 226 / 226 | 67% | 6.25 | 272 / 406 |
spleen | 100% | 2319.99 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.14 | 1 / 1 |
blood vessel | 100% | 1640.17 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 2012.23 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 1059.28 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1062.13 | 834 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 17.48 | 43 / 45 |
lymph node | 0% | 0 | 0 / 0 | 93% | 14.93 | 27 / 29 |
eye | 0% | 0 | 0 / 0 | 80% | 11.90 | 64 / 80 |
peripheral blood | 41% | 981.08 | 380 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006338 | Biological process | chromatin remodeling |
GO_0000018 | Biological process | regulation of DNA recombination |
GO_0000729 | Biological process | DNA double-strand break processing |
GO_0051304 | Biological process | chromosome separation |
GO_0000792 | Cellular component | heterochromatin |
GO_0043596 | Cellular component | nuclear replication fork |
GO_0005654 | Cellular component | nucleoplasm |
GO_0035861 | Cellular component | site of double-strand break |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
GO_0008094 | Molecular function | ATP-dependent activity, acting on DNA |
GO_0004386 | Molecular function | helicase activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0043130 | Molecular function | ubiquitin binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | SMARCAD1 |
Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-containing DEAD/H box 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) |
Synonyms | KIAA1122 |
Description | FUNCTION: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. . |
Accessions | ENST00000359052.8 [Q9H4L7-2] Q9H4L7 ENST00000509418.1 [Q9H4L7-3] D6RAY8 ENST00000510105.5 F8W9M2 ENST00000457823.6 [Q9H4L7-2] ENST00000354268.9 [Q9H4L7-1] ENST00000394961.6 |