SMARCAD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0000018Biological processregulation of DNA recombination
GO_0000729Biological processDNA double-strand break processing
GO_0051304Biological processchromosome separation
GO_0000792Cellular componentheterochromatin
GO_0043596Cellular componentnuclear replication fork
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0004386Molecular functionhelicase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0043130Molecular functionubiquitin binding
GO_0003682Molecular functionchromatin binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameSMARCAD1
Protein nameSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-containing DEAD/H box 1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)
SynonymsKIAA1122
DescriptionFUNCTION: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. .

AccessionsENST00000359052.8 [Q9H4L7-2]
Q9H4L7
ENST00000509418.1 [Q9H4L7-3]
D6RAY8
ENST00000510105.5
F8W9M2
ENST00000457823.6 [Q9H4L7-2]
ENST00000354268.9 [Q9H4L7-1]
ENST00000394961.6