KDM4D report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KDM4D at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KDM4D at tissue level.

III. Associated gene sets

GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0010468Biological processregulation of gene expression
GO_0006954Biological processinflammatory response
GO_0001932Biological processregulation of protein phosphorylation
GO_0006338Biological processchromatin remodeling
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0035563Biological processpositive regulation of chromatin binding
GO_0071479Biological processcellular response to ionizing radiation
GO_0005654Cellular componentnucleoplasm
GO_0072562Cellular componentblood microparticle
GO_0005721Cellular componentpericentric heterochromatin
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0032454Molecular functionhistone H3K9 demethylase activity
GO_0032452Molecular functionhistone demethylase activity
GO_0046872Molecular functionmetal ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0140684Molecular functionhistone H3K9me2/H3K9me3 demethylase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameKDM4D
Protein nameLysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D)
SynonymsJHDM3D
JMJD2D
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. .

AccessionsQ6B0I6
ENST00000536741.1
ENST00000335080.6
ENST00000610872.1