INTS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006974Biological processDNA damage response
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0034243Biological processregulation of transcription elongation by RNA polymerase II
GO_0016180Biological processsnRNA processing
GO_0006281Biological processDNA repair
GO_0010212Biological processresponse to ionizing radiation
GO_0070876Cellular componentSOSS complex
GO_0032039Cellular componentintegrator complex
GO_0005654Cellular componentnucleoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameINTS3
Protein nameIntegrator complex subunit 3
Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A)
SynonymsC1orf60
C1orf193
DescriptionFUNCTION: Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex . .; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. .

AccessionsENST00000623139.1
ENST00000503133.5
H0Y8Z1
ENST00000571768.5 [Q68E01-2]
ENST00000576422.4 [Q68E01-3]
ENST00000624515.1
ENST00000575708.5
ENST00000476843.5
ENST00000435409.6 [Q68E01-2]
ENST00000575774.5
ENST00000576030.5 [Q68E01-2]
ENST00000512605.4 [Q68E01-3]
A0A096LPB9
ENST00000318967.7 [Q68E01-2]
A0A096LNW8
Q68E01