DDB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006281Biological processDNA repair
GO_0051093Biological processnegative regulation of developmental process
GO_0034644Biological processcellular response to UV
GO_0046726Biological processpositive regulation by virus of viral protein levels in host cell
GO_0010498Biological processproteasomal protein catabolic process
GO_0006289Biological processnucleotide-excision repair
GO_0070914Biological processUV-damage excision repair
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051702Biological processbiological process involved in interaction with symbiont
GO_0042752Biological processregulation of circadian rhythm
GO_0045070Biological processpositive regulation of viral genome replication
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007056Biological processspindle assembly involved in female meiosis
GO_2000242Biological processnegative regulation of reproductive process
GO_0019076Biological processviral release from host cell
GO_0006915Biological processapoptotic process
GO_0016055Biological processWnt signaling pathway
GO_1901990Biological processregulation of mitotic cell cycle phase transition
GO_0048511Biological processrhythmic process
GO_0035234Biological processectopic germ cell programmed cell death
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0044725Biological processepigenetic programming in the zygotic pronuclei
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0031465Cellular componentCul4B-RING E3 ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0160072Molecular functionubiquitin ligase complex scaffold activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0097602Molecular functioncullin family protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0071987Molecular functionWD40-repeat domain binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameDDB1
Protein nameDNA damage-binding protein 1 (Damage-specific DNA-binding protein 1)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
SynonymsXAP1
DescriptionFUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively . Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair . The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches . Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins . The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 . DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage . The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair . DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER . DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication . DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) . The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 . DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

FUNCTION: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock. .

AccessionsA0A7P0Z4B9
A0A7P0T965
ENST00000535283.6
ENST00000542337.5
F5GWI0
A0A7P0T870
A0A7P0Z4L2
F5H198
ENST00000681803.1 [Q16531-1]
F5H2L3
ENST00000679588.1
ENST00000680357.1
A0A7P0TB30
ENST00000681188.1
ENST00000681935.1
ENST00000540166.5
ENST00000680602.1
ENST00000301764.12 [Q16531-1]
F5GZY8
A0A7P0Z3Z5
A0A7P0TAX4
F5GY55
ENST00000680717.1
ENST00000680075.1
ENST00000543658.5
A0A7P0TAK7
ENST00000680367.1 [Q16531-1]
Q16531
ENST00000679712.1
ENST00000539426.5