TIMELESS report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TIMELESS at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIMELESS at tissue level.

III. Associated gene sets

GO_0030324Biological processlung development
GO_0006281Biological processDNA repair
GO_0002009Biological processmorphogenesis of an epithelium
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0006974Biological processDNA damage response
GO_0072711Biological processcellular response to hydroxyurea
GO_0043111Biological processreplication fork arrest
GO_1904976Biological processcellular response to bleomycin
GO_0051301Biological processcell division
GO_0007623Biological processcircadian rhythm
GO_0042752Biological processregulation of circadian rhythm
GO_0042127Biological processregulation of cell population proliferation
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0044770Biological processcell cycle phase transition
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0000076Biological processDNA replication checkpoint signaling
GO_0009582Biological processdetection of abiotic stimulus
GO_0072719Biological processcellular response to cisplatin
GO_0005654Cellular componentnucleoplasm
GO_0031298Cellular componentreplication fork protection complex
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTIMELESS
Protein nameProtein timeless homolog (hTIM)
SynonymsTIM
TIM1
TIMELESS1
DescriptionFUNCTION: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock . Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress . During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis . TIMELESS promotes TIPIN nuclear localization . Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 . Involved in cell survival after DNA damage or replication stress by promoting DNA repair . In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 . May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light . Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock . Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus . May play a role as destabilizer of the PER2-CRY2 complex . May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). .

AccessionsQ9UNS1
ENST00000553532.6 [Q9UNS1-1]
ENST00000229201.4 [Q9UNS1-2]