RBX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0062197Biological processcellular response to chemical stress
GO_0006281Biological processDNA repair
GO_0007283Biological processspermatogenesis
GO_0000209Biological processprotein polyubiquitination
GO_0000165Biological processMAPK cascade
GO_0034644Biological processcellular response to UV
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_1902883Biological processnegative regulation of response to oxidative stress
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0043687Biological processpost-translational protein modification
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0032480Biological processnegative regulation of type I interferon production
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045116Biological processprotein neddylation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0071230Biological processcellular response to amino acid stimulus
GO_1902499Biological processpositive regulation of protein autoubiquitination
GO_0006513Biological processprotein monoubiquitination
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_1900076Biological processregulation of cellular response to insulin stimulus
GO_0042110Biological processT cell activation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0031466Cellular componentCul5-RING ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0031465Cellular componentCul4B-RING E3 ubiquitin ligase complex
GO_0031461Cellular componentcullin-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0031467Cellular componentCul7-RING ubiquitin ligase complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0061663Molecular functionNEDD8 ligase activity
GO_0097602Molecular functioncullin family protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0019788Molecular functionNEDD8 transferase activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBX1
Protein nameE3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
SynonymsROC1
RNF75
DescriptionFUNCTION: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair . CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets . The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A . .

AccessionsENST00000216225.9
P62877