GO_0045116 | protein neddylation | OmnibusX

protein neddylation

I. Involved cell types

	Genes	Cell types	No. of supported studies
Group 1	DCUN1D3	epithelial cell squamous epithelial cell	3 studies
Group 2	UBE2M GPS1 COPS3 RBX1 NAE1 AKTIP NEDD8 COPS2 COPS7A DCUN1D5 COPS5 COPS6 DCUN1D4 COPS4 UBA3 DCUN1D1 RNF7 COPS8	dopaminergic neuron	6 studies
Group 3	DCUN1D2	dopaminergic neuron glutamatergic neuron GABAergic neuron interneuron	11 studies
Group 4	UBE2F	myeloid cell lymphocyte epithelial cell	38 studies

II. Literature review

Name	protein neddylation
ID	GO_0045116
collection_id	Biological process
Alternative ID	GO:0019943
Exact synonym	RUB1-protein conjugation
Description	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
Comment	Note that currently, the only known substrates of neddylation are cullin family proteins.
External URL
Genes	COPS2 DCUN1D5 RNF7 NAE1 TRIM40 DCUN1D3 UBE2M GPS1 COPS3 COPS5 COPS4 COPS6 COPS7A AKTIP COPS8 NEDD8 DCUN1D2 DCUN1D1 UBE2F DCUN1D4 UBA3 cop9_human-1 RBX1