COPS8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000434Biological processregulation of protein neddylation
GO_0007250Biological processactivation of NF-kappaB-inducing kinase activity
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006468Biological processprotein phosphorylation
GO_0045116Biological processprotein neddylation
GO_0000338Biological processprotein deneddylation
GO_0010387Biological processCOP9 signalosome assembly
GO_0008180Cellular componentCOP9 signalosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOPS8
Protein nameCOP9 signalosome subunit 8
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)
SynonymsCSN8
DescriptionFUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. .

AccessionsENST00000419015.1
ENST00000409334.5
H7C3S9
Q99627
E9PGT6
ENST00000354371.7 [Q99627-1]
ENST00000447464.1
ENST00000392008.6 [Q99627-2]
F8WEF2