UBA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045116Biological processprotein neddylation
GO_0036211Biological processprotein modification process
GO_0006508Biological processproteolysis
GO_0007113Biological processendomitotic cell cycle
GO_0043687Biological processpost-translational protein modification
GO_0051726Biological processregulation of cell cycle
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0019788Molecular functionNEDD8 transferase activity
GO_0019781Molecular functionNEDD8 activating enzyme activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameUBA3
Protein nameNEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)
Ubiquitin like modifier activating enzyme 3
NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64)
SynonymsUBE1C
DescriptionFUNCTION: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. .

FUNCTION: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. .

FUNCTION: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. .

AccessionsENST00000361055.9 [Q8TBC4-1]
ENST00000349511.8 [Q8TBC4-2]
ENST00000415609.6
F8WF86
F8W8D4
Q8TBC4
F8WAT6
ENST00000465627.5
ENST00000461934.5
ENST00000630585.1