Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 24% ± 6% | |
oligodendrocyte | 7 studies | 28% ± 8% | |
microglial cell | 6 studies | 25% ± 7% | |
fibroblast | 6 studies | 20% ± 4% | |
epithelial cell | 6 studies | 31% ± 12% | |
retinal cone cell | 6 studies | 33% ± 14% | |
retinal rod cell | 6 studies | 27% ± 7% | |
astrocyte | 6 studies | 29% ± 9% | |
ciliated cell | 5 studies | 24% ± 6% | |
macrophage | 5 studies | 23% ± 4% | |
GABAergic neuron | 5 studies | 42% ± 18% | |
oligodendrocyte precursor cell | 5 studies | 32% ± 7% | |
interneuron | 5 studies | 32% ± 19% | |
classical monocyte | 4 studies | 23% ± 6% | |
neuron | 4 studies | 28% ± 10% | |
pericyte | 4 studies | 17% ± 1% | |
regulatory T cell | 4 studies | 17% ± 1% | |
glutamatergic neuron | 4 studies | 54% ± 14% | |
monocyte | 4 studies | 20% ± 2% | |
non-classical monocyte | 3 studies | 25% ± 7% | |
retinal ganglion cell | 3 studies | 38% ± 15% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 17% ± 2% | |
retina horizontal cell | 3 studies | 23% ± 6% | |
lymphocyte | 3 studies | 20% ± 4% | |
type I pneumocyte | 3 studies | 20% ± 2% | |
basal cell | 3 studies | 34% ± 4% | |
transit amplifying cell | 3 studies | 27% ± 15% | |
plasmacytoid dendritic cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2194.81 | 2642 / 2642 | 100% | 43.67 | 705 / 705 |
esophagus | 100% | 2419.54 | 1445 / 1445 | 100% | 30.76 | 183 / 183 |
lung | 100% | 2293.95 | 578 / 578 | 100% | 33.27 | 1155 / 1155 |
ovary | 100% | 2153.69 | 180 / 180 | 100% | 34.52 | 430 / 430 |
uterus | 100% | 2513.19 | 170 / 170 | 100% | 35.35 | 459 / 459 |
breast | 100% | 2367.51 | 459 / 459 | 100% | 43.58 | 1117 / 1118 |
intestine | 100% | 2342.00 | 966 / 966 | 100% | 33.00 | 526 / 527 |
bladder | 100% | 2267.95 | 21 / 21 | 100% | 35.91 | 503 / 504 |
stomach | 100% | 1622.13 | 359 / 359 | 100% | 33.54 | 285 / 286 |
prostate | 100% | 2196.69 | 245 / 245 | 100% | 33.84 | 500 / 502 |
thymus | 100% | 2031.61 | 653 / 653 | 99% | 28.90 | 601 / 605 |
kidney | 100% | 1730.39 | 89 / 89 | 99% | 24.52 | 890 / 901 |
adrenal gland | 100% | 2657.84 | 258 / 258 | 98% | 21.18 | 225 / 230 |
pancreas | 98% | 980.81 | 323 / 328 | 99% | 28.70 | 176 / 178 |
skin | 100% | 2820.55 | 1809 / 1809 | 96% | 32.84 | 454 / 472 |
liver | 100% | 1037.08 | 226 / 226 | 95% | 13.99 | 386 / 406 |
adipose | 100% | 2286.64 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 40.60 | 29 / 29 |
spleen | 100% | 3111.00 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 31.95 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 17.18 | 1 / 1 |
blood vessel | 100% | 2252.89 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1771.49 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 2267.58 | 850 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 2293.96 | 863 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 66% | 8.83 | 53 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045116 | Biological process | protein neddylation |
GO_0036211 | Biological process | protein modification process |
GO_0006508 | Biological process | proteolysis |
GO_0007113 | Biological process | endomitotic cell cycle |
GO_0043687 | Biological process | post-translational protein modification |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0019788 | Molecular function | NEDD8 transferase activity |
GO_0019781 | Molecular function | NEDD8 activating enzyme activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | UBA3 |
Protein name | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) Ubiquitin like modifier activating enzyme 3 NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) |
Synonyms | UBE1C |
Description | FUNCTION: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. . FUNCTION: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. . FUNCTION: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. . |
Accessions | ENST00000361055.9 [Q8TBC4-1] ENST00000349511.8 [Q8TBC4-2] ENST00000415609.6 F8WF86 F8W8D4 Q8TBC4 F8WAT6 ENST00000465627.5 ENST00000461934.5 ENST00000630585.1 |