DCUN1D3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DCUN1D3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DCUN1D3 at tissue level.

III. Associated gene sets

GO_0010332Biological processresponse to gamma radiation
GO_0010225Biological processresponse to UV-C
GO_2000435Biological processnegative regulation of protein neddylation
GO_2000434Biological processregulation of protein neddylation
GO_0045116Biological processprotein neddylation
GO_0010564Biological processregulation of cell cycle process
GO_2000436Biological processpositive regulation of protein neddylation
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030308Biological processnegative regulation of cell growth
GO_0000151Cellular componentubiquitin ligase complex
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097602Molecular functioncullin family protein binding
GO_0032182Molecular functionubiquitin-like protein binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function
GO_0031624Molecular functionubiquitin conjugating enzyme binding

IV. Literature review

[source]
Gene nameDCUN1D3
Protein nameDCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
SynonymsSCCRO3
DescriptionFUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage . At the cell membrane, can promote and as well inhibit cullins neddylation . .

AccessionsENST00000324344.9
Q8IWE4
ENST00000563934.1