Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 25% ± 6% | |
smooth muscle cell | 8 studies | 24% ± 5% | |
pericyte | 7 studies | 22% ± 5% | |
B cell | 6 studies | 26% ± 7% | |
natural killer cell | 6 studies | 26% ± 9% | |
epithelial cell | 6 studies | 39% ± 18% | |
ciliated cell | 6 studies | 34% ± 16% | |
fibroblast | 6 studies | 20% ± 4% | |
basal cell | 5 studies | 29% ± 19% | |
classical monocyte | 4 studies | 38% ± 19% | |
neuron | 4 studies | 32% ± 12% | |
myeloid cell | 4 studies | 26% ± 8% | |
mast cell | 3 studies | 20% ± 3% | |
leukocyte | 3 studies | 27% ± 7% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 20% ± 4% | |
non-classical monocyte | 3 studies | 47% ± 16% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 30% ± 11% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 33% ± 10% | |
hematopoietic precursor cell | 3 studies | 27% ± 15% | |
mature NK T cell | 3 studies | 24% ± 7% | |
plasmablast | 3 studies | 32% ± 18% | |
glutamatergic neuron | 3 studies | 39% ± 17% | |
retinal ganglion cell | 3 studies | 40% ± 13% | |
myofibroblast cell | 3 studies | 21% ± 6% | |
plasma cell | 3 studies | 32% ± 17% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 21% ± 4% | |
gamma-delta T cell | 3 studies | 34% ± 8% | |
macrophage | 3 studies | 21% ± 7% | |
GABAergic neuron | 3 studies | 29% ± 8% | |
goblet cell | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 3733.88 | 258 / 258 | 100% | 199.22 | 230 / 230 |
esophagus | 100% | 3478.40 | 1445 / 1445 | 100% | 129.00 | 183 / 183 |
ovary | 100% | 2557.90 | 180 / 180 | 100% | 165.69 | 430 / 430 |
uterus | 100% | 2795.32 | 170 / 170 | 100% | 177.80 | 459 / 459 |
brain | 100% | 5678.54 | 2641 / 2642 | 100% | 143.24 | 705 / 705 |
skin | 100% | 3149.77 | 1808 / 1809 | 100% | 197.04 | 472 / 472 |
kidney | 100% | 3060.52 | 89 / 89 | 100% | 102.02 | 899 / 901 |
thymus | 100% | 2851.05 | 651 / 653 | 100% | 142.89 | 605 / 605 |
intestine | 100% | 3353.85 | 966 / 966 | 100% | 131.29 | 525 / 527 |
prostate | 100% | 3081.55 | 245 / 245 | 100% | 152.16 | 500 / 502 |
liver | 100% | 1487.92 | 225 / 226 | 100% | 97.63 | 406 / 406 |
stomach | 100% | 2576.17 | 359 / 359 | 99% | 128.92 | 284 / 286 |
bladder | 100% | 3344.86 | 21 / 21 | 99% | 157.20 | 500 / 504 |
breast | 100% | 2538.52 | 459 / 459 | 99% | 130.19 | 1109 / 1118 |
lung | 100% | 2754.43 | 576 / 578 | 99% | 125.60 | 1147 / 1155 |
pancreas | 98% | 1330.15 | 322 / 328 | 99% | 124.39 | 177 / 178 |
eye | 0% | 0 | 0 / 0 | 100% | 193.38 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 196.50 | 29 / 29 |
muscle | 100% | 4773.60 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2913.10 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 164.41 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 108.60 | 1 / 1 |
blood vessel | 100% | 3231.99 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 2559.23 | 1203 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 3761.91 | 928 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 3844.35 | 853 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045116 | Biological process | protein neddylation |
GO_0036211 | Biological process | protein modification process |
GO_0043687 | Biological process | post-translational protein modification |
GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0019788 | Molecular function | NEDD8 transferase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0061654 | Molecular function | NEDD8 conjugating enzyme activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | UBE2M |
Protein name | E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) Ubiquitin conjugating enzyme E2 M Epididymis secretory sperm binding protein (Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_a) NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) |
Synonyms | hCG_2045958 UBC12 |
Description | FUNCTION: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. . |
Accessions | ENST00000596985.1 ENST00000595957.5 M0QYI6 ENST00000253023.8 P61081 M0QX69 A0A024R4T4 |