UBE2M report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045116Biological processprotein neddylation
GO_0036211Biological processprotein modification process
GO_0043687Biological processpost-translational protein modification
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0019788Molecular functionNEDD8 transferase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061654Molecular functionNEDD8 conjugating enzyme activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameUBE2M
Protein nameE2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
Ubiquitin conjugating enzyme E2 M
Epididymis secretory sperm binding protein (Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), isoform CRA_a)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
SynonymshCG_2045958
UBC12
DescriptionFUNCTION: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. .

AccessionsENST00000596985.1
ENST00000595957.5
M0QYI6
ENST00000253023.8
P61081
M0QX69
A0A024R4T4