RNF7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	31 studies	31% ± 10%	Explore
CD8-positive, alpha-beta T cell	29 studies	30% ± 11%	Explore
endothelial cell	28 studies	38% ± 14%	Explore
B cell	27 studies	24% ± 9%	Explore
fibroblast	27 studies	34% ± 12%	Explore
CD4-positive, alpha-beta T cell	27 studies	28% ± 10%	Explore
macrophage	26 studies	30% ± 9%	Explore
classical monocyte	25 studies	37% ± 13%	Explore
conventional dendritic cell	25 studies	33% ± 15%	Explore
pericyte	25 studies	33% ± 12%	Explore
smooth muscle cell	23 studies	33% ± 12%	Explore
T cell	22 studies	27% ± 7%	Explore
non-classical monocyte	22 studies	38% ± 15%	Explore
regulatory T cell	19 studies	32% ± 8%	Explore
basal cell	18 studies	39% ± 19%	Explore
epithelial cell	18 studies	42% ± 19%	Explore
plasmacytoid dendritic cell	17 studies	32% ± 12%	Explore
mature NK T cell	17 studies	30% ± 7%	Explore
mast cell	16 studies	30% ± 13%	Explore
monocyte	16 studies	34% ± 8%	Explore
memory B cell	16 studies	23% ± 5%	Explore
gamma-delta T cell	16 studies	32% ± 14%	Explore
endothelial cell of lymphatic vessel	15 studies	33% ± 11%	Explore
connective tissue cell	15 studies	37% ± 15%	Explore
naive B cell	14 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	35% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	26% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	30% ± 9%	Explore
myofibroblast cell	13 studies	36% ± 12%	Explore
dendritic cell	12 studies	41% ± 24%	Explore
ciliated cell	12 studies	41% ± 19%	Explore
plasma cell	11 studies	31% ± 12%	Explore
secretory cell	11 studies	33% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	31% ± 7%	Explore
capillary endothelial cell	11 studies	29% ± 16%	Explore
endothelial cell of artery	11 studies	33% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	35% ± 11%	Explore
vein endothelial cell	10 studies	30% ± 13%	Explore
mucosal invariant T cell	10 studies	30% ± 7%	Explore
progenitor cell	9 studies	37% ± 13%	Explore
abnormal cell	9 studies	32% ± 17%	Explore
endothelial cell of vascular tree	9 studies	28% ± 7%	Explore
myeloid cell	9 studies	32% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	35% ± 13%	Explore
enterocyte	8 studies	31% ± 11%	Explore
goblet cell	8 studies	30% ± 15%	Explore
type I pneumocyte	7 studies	27% ± 12%	Explore
club cell	7 studies	40% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	36% ± 10%	Explore
leukocyte	7 studies	29% ± 5%	Explore
epithelial cell of proximal tubule	7 studies	27% ± 8%	Explore
T follicular helper cell	7 studies	27% ± 4%	Explore
plasmablast	6 studies	44% ± 22%	Explore
respiratory goblet cell	6 studies	39% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	24% ± 6%	Explore
mesothelial cell	6 studies	49% ± 16%	Explore
precursor B cell	6 studies	33% ± 12%	Explore
innate lymphoid cell	6 studies	26% ± 5%	Explore
alveolar macrophage	5 studies	26% ± 3%	Explore
exhausted T cell	5 studies	43% ± 12%	Explore
mononuclear phagocyte	5 studies	32% ± 15%	Explore
intestinal crypt stem cell	5 studies	26% ± 9%	Explore
hematopoietic stem cell	5 studies	31% ± 7%	Explore
neuron	5 studies	50% ± 20%	Explore
type II pneumocyte	5 studies	37% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	39% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	38% ± 14%	Explore
hematopoietic precursor cell	4 studies	48% ± 21%	Explore
pancreatic A cell	4 studies	58% ± 14%	Explore
type B pancreatic cell	4 studies	58% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	36% ± 5%	Explore
enteroendocrine cell	4 studies	50% ± 11%	Explore
transit amplifying cell	4 studies	18% ± 2%	Explore
pro-B cell	4 studies	34% ± 7%	Explore
immature B cell	4 studies	23% ± 4%	Explore
adventitial cell	4 studies	21% ± 4%	Explore
intermediate monocyte	4 studies	53% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 3%	Explore
T-helper 17 cell	4 studies	29% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 8%	Explore
duct epithelial cell	3 studies	30% ± 18%	Explore
precursor cell	3 studies	52% ± 16%	Explore
squamous epithelial cell	3 studies	40% ± 25%	Explore
pancreatic D cell	3 studies	56% ± 17%	Explore
glomerular endothelial cell	3 studies	26% ± 3%	Explore
renal alpha-intercalated cell	3 studies	33% ± 8%	Explore
neural crest cell	3 studies	44% ± 10%	Explore
extravillous trophoblast	3 studies	34% ± 8%	Explore
lymphocyte	3 studies	35% ± 13%	Explore
brush cell	3 studies	33% ± 19%	Explore
amacrine cell	3 studies	33% ± 7%	Explore
retinal cone cell	3 studies	59% ± 15%	Explore
retinal rod cell	3 studies	27% ± 9%	Explore
microglial cell	3 studies	24% ± 8%	Explore
serous secreting cell	3 studies	31% ± 5%	Explore
intraepithelial lymphocyte	3 studies	31% ± 13%	Explore
Mueller cell	3 studies	23% ± 5%	Explore
muscle cell	3 studies	31% ± 20%	Explore
germinal center B cell	3 studies	26% ± 5%	Explore
myoepithelial cell	3 studies	35% ± 8%	Explore
acinar cell	3 studies	37% ± 10%	Explore
pancreatic ductal cell	3 studies	67% ± 4%	Explore
oligodendrocyte precursor cell	3 studies	33% ± 14%	Explore
granulocyte	3 studies	28% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 14%	Explore
keratinocyte	3 studies	29% ± 5%	Explore
neutrophil	3 studies	17% ± 1%	Explore
T-helper 1 cell	3 studies	31% ± 7%	Explore
double negative thymocyte	3 studies	50% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	37% ± 17%	Explore
peripheral blood	16 studies	34% ± 11%	Explore
kidney	8 studies	29% ± 7%	Explore
intestine	8 studies	34% ± 15%	Explore
lymph node	5 studies	31% ± 13%	Explore
liver	5 studies	25% ± 12%	Explore
pancreas	4 studies	58% ± 14%	Explore
placenta	4 studies	30% ± 9%	Explore
eye	4 studies	29% ± 11%	Explore
uterus	4 studies	38% ± 15%	Explore
breast	4 studies	28% ± 5%	Explore
brain	4 studies	26% ± 5%	Explore
bone marrow	3 studies	29% ± 9%	Explore
adrenal gland	3 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4520.02	258 / 258	100%	48.06	230 / 230
bladder	100%	3275.52	21 / 21	100%	61.52	504 / 504
esophagus	100%	3028.21	1445 / 1445	100%	59.39	183 / 183
kidney	100%	3107.58	89 / 89	100%	47.31	901 / 901
liver	100%	1791.48	226 / 226	100%	34.76	406 / 406
lung	100%	2615.38	578 / 578	100%	68.07	1155 / 1155
ovary	100%	3073.63	180 / 180	100%	64.35	430 / 430
pancreas	100%	1871.00	328 / 328	100%	53.97	178 / 178
skin	100%	3399.97	1809 / 1809	100%	49.01	472 / 472
stomach	100%	2284.11	359 / 359	100%	46.43	286 / 286
thymus	100%	2464.47	653 / 653	100%	53.63	605 / 605
uterus	100%	2780.78	170 / 170	100%	75.46	459 / 459
brain	100%	2254.19	2637 / 2642	100%	41.05	705 / 705
intestine	100%	3577.93	966 / 966	100%	47.70	526 / 527
prostate	100%	3374.20	245 / 245	100%	57.06	501 / 502
breast	100%	2853.14	459 / 459	100%	59.13	1115 / 1118
adipose	100%	2779.46	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3660.02	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	27.68	80 / 80
lymph node	0%	0	0 / 0	100%	47.73	29 / 29
muscle	100%	3580.44	803 / 803	0%	0	0 / 0
spleen	100%	2486.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	68.96	45 / 45
ureter	0%	0	0 / 0	100%	44.27	1 / 1
heart	99%	2438.87	854 / 861	0%	0	0 / 0
peripheral blood	93%	1651.00	868 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0045116	Biological process	protein neddylation
GO_0051775	Biological process	response to redox state
GO_0043687	Biological process	post-translational protein modification
GO_0031466	Cellular component	Cul5-RING ubiquitin ligase complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0019788	Molecular function	NEDD8 transferase activity
GO_0005507	Molecular function	copper ion binding
GO_0061663	Molecular function	NEDD8 ligase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0097602	Molecular function	cullin family protein binding

IV. Literature review

[source]

Gene name	RNF7
Protein name	Ring finger protein 7 RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Synonyms	RBX2 SAG ROC2
Description	FUNCTION: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription . CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. .
Accessions	Q9UBF6 F8WEU8 ENST00000393000.3 [Q9UBF6-3] ENST00000477012.5 [Q9UBF6-2] ENST00000477393.1 ENST00000273480.4 [Q9UBF6-1] ENST00000480908.1 [Q9UBF6-4]

RNF7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review