COPS3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	11 studies	23% ± 7%	Explore
conventional dendritic cell	10 studies	26% ± 15%	Explore
CD8-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
CD4-positive, alpha-beta T cell	8 studies	25% ± 6%	Explore
plasma cell	6 studies	24% ± 12%	Explore
dendritic cell	6 studies	30% ± 19%	Explore
regulatory T cell	6 studies	19% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 2%	Explore
endothelial cell	5 studies	23% ± 8%	Explore
erythrocyte	5 studies	36% ± 19%	Explore
gamma-delta T cell	5 studies	25% ± 19%	Explore
hematopoietic precursor cell	4 studies	32% ± 12%	Explore
plasmablast	4 studies	49% ± 19%	Explore
non-classical monocyte	4 studies	28% ± 9%	Explore
B cell	4 studies	22% ± 7%	Explore
erythroblast	4 studies	39% ± 21%	Explore
pro-B cell	4 studies	25% ± 3%	Explore
smooth muscle cell	4 studies	19% ± 3%	Explore
epithelial cell	4 studies	39% ± 13%	Explore
precursor B cell	4 studies	25% ± 10%	Explore
fibroblast	4 studies	23% ± 6%	Explore
ciliated cell	4 studies	26% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	23% ± 8%	Explore
glutamatergic neuron	4 studies	28% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 6%	Explore
neuron	4 studies	25% ± 12%	Explore
plasmacytoid dendritic cell	4 studies	21% ± 6%	Explore
T cell	4 studies	22% ± 3%	Explore
pancreatic A cell	3 studies	30% ± 6%	Explore
type B pancreatic cell	3 studies	28% ± 6%	Explore
classical monocyte	3 studies	28% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
mature NK T cell	3 studies	15% ± 0%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	18% ± 3%	Explore
pericyte	3 studies	25% ± 7%	Explore
GABAergic neuron	3 studies	26% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	38% ± 23%	Explore
intestinal crypt stem cell	3 studies	18% ± 2%	Explore
basal cell	3 studies	33% ± 11%	Explore
double negative thymocyte	3 studies	29% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	21% ± 5%	Explore
peripheral blood	4 studies	25% ± 7%	Explore
lung	4 studies	24% ± 8%	Explore
pancreas	3 studies	28% ± 6%	Explore
liver	3 studies	36% ± 26%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2665.99	1445 / 1445	100%	58.52	183 / 183
ovary	100%	1892.72	180 / 180	100%	40.52	430 / 430
pancreas	100%	1766.02	328 / 328	100%	40.94	178 / 178
stomach	100%	2016.74	359 / 359	100%	49.67	286 / 286
uterus	100%	2299.79	170 / 170	100%	81.11	459 / 459
intestine	100%	2453.35	966 / 966	100%	52.70	526 / 527
prostate	100%	2238.38	245 / 245	100%	56.38	501 / 502
breast	100%	2401.27	459 / 459	100%	62.47	1115 / 1118
thymus	100%	1984.94	651 / 653	100%	56.44	604 / 605
lung	99%	2027.98	575 / 578	100%	61.98	1155 / 1155
bladder	100%	2490.90	21 / 21	99%	57.64	500 / 504
skin	100%	3014.81	1809 / 1809	99%	59.32	468 / 472
brain	99%	2337.88	2618 / 2642	100%	68.43	705 / 705
kidney	100%	1687.83	89 / 89	99%	41.26	890 / 901
adrenal gland	100%	2253.05	258 / 258	98%	51.41	226 / 230
liver	99%	1220.66	223 / 226	99%	30.95	401 / 406
adipose	100%	2430.01	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	87.23	29 / 29
muscle	100%	6996.88	803 / 803	0%	0	0 / 0
spleen	100%	2161.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	94.68	45 / 45
ureter	0%	0	0 / 0	100%	11.35	1 / 1
blood vessel	100%	2125.11	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	2525.91	917 / 929	0%	0	0 / 0
heart	96%	2418.95	828 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	37.31	76 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_2000434	Biological process	regulation of protein neddylation
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0009416	Biological process	response to light stimulus
GO_0045116	Biological process	protein neddylation
GO_1902162	Biological process	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0001701	Biological process	in utero embryonic development
GO_0000338	Biological process	protein deneddylation
GO_0008180	Cellular component	COP9 signalosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	COPS3
Protein name	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) COP9 signalosome subunit 3 COP9 signalosome complex subunit 3
Synonyms	CSN3
Description	FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. .
Accessions	ENST00000579716.2 J3QS85 ENST00000492672.5 H7C3P9 ENST00000578317.5 ENST00000417352.5 ENST00000577246.5 C9JLV5 J3KTQ1 Q9UNS2 ENST00000584216.5 ENST00000268717.10 [Q9UNS2-1] J3QL22 ENST00000439936.6 ENST00000477299.5 ENST00000583160.5 K7ELN6 ENST00000577210.5 ENST00000495640.1 K7ES36 J3QKR0 K7EJF9 ENST00000539941.6 [Q9UNS2-2]

COPS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review