GPS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	9 studies	21% ± 5%	Explore
CD8-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	21% ± 5%	Explore
endothelial cell	6 studies	22% ± 8%	Explore
epithelial cell	6 studies	31% ± 13%	Explore
classical monocyte	5 studies	23% ± 8%	Explore
mature NK T cell	5 studies	16% ± 0%	Explore
plasmacytoid dendritic cell	5 studies	22% ± 6%	Explore
conventional dendritic cell	4 studies	30% ± 13%	Explore
non-classical monocyte	4 studies	26% ± 7%	Explore
smooth muscle cell	4 studies	20% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	21% ± 3%	Explore
fibroblast	4 studies	23% ± 6%	Explore
ciliated cell	4 studies	27% ± 5%	Explore
macrophage	4 studies	21% ± 5%	Explore
regulatory T cell	4 studies	19% ± 1%	Explore
gamma-delta T cell	4 studies	24% ± 11%	Explore
plasmablast	3 studies	50% ± 11%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
hematopoietic precursor cell	3 studies	22% ± 3%	Explore
connective tissue cell	3 studies	18% ± 3%	Explore
pericyte	3 studies	21% ± 3%	Explore
myofibroblast cell	3 studies	19% ± 1%	Explore
type I pneumocyte	3 studies	21% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
astrocyte	3 studies	18% ± 2%	Explore
dendritic cell	3 studies	36% ± 7%	Explore
neuron	3 studies	28% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	19% ± 5%	Explore
lung	4 studies	18% ± 3%	Explore
brain	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4685.09	1445 / 1445	100%	45.18	183 / 183
liver	100%	4720.59	226 / 226	100%	60.71	406 / 406
ovary	100%	5452.28	180 / 180	100%	77.11	430 / 430
pancreas	100%	3242.60	328 / 328	100%	47.83	178 / 178
thymus	100%	6420.77	653 / 653	100%	59.91	605 / 605
brain	100%	5598.29	2641 / 2642	100%	76.68	705 / 705
prostate	100%	6897.85	245 / 245	100%	81.34	501 / 502
skin	100%	5404.76	1809 / 1809	100%	85.09	471 / 472
uterus	100%	5602.70	170 / 170	100%	70.62	458 / 459
adrenal gland	100%	5599.31	258 / 258	100%	55.99	229 / 230
kidney	100%	6302.85	89 / 89	99%	49.50	895 / 901
stomach	100%	4538.90	359 / 359	99%	53.88	284 / 286
intestine	100%	5137.94	966 / 966	99%	58.09	523 / 527
lung	100%	4930.58	578 / 578	99%	58.99	1144 / 1155
breast	100%	5482.14	459 / 459	99%	63.29	1107 / 1118
bladder	100%	5163.67	21 / 21	99%	71.99	499 / 504
adipose	100%	5234.15	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	84.97	80 / 80
lymph node	0%	0	0 / 0	100%	67.83	29 / 29
muscle	100%	7368.93	803 / 803	0%	0	0 / 0
spleen	100%	5524.26	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	52.41	45 / 45
ureter	0%	0	0 / 0	100%	67.72	1 / 1
blood vessel	100%	4607.35	1334 / 1335	0%	0	0 / 0
heart	99%	4327.69	855 / 861	0%	0	0 / 0
peripheral blood	98%	3105.87	912 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000434	Biological process	regulation of protein neddylation
GO_0007254	Biological process	JNK cascade
GO_0045116	Biological process	protein neddylation
GO_0000338	Biological process	protein deneddylation
GO_0008180	Cellular component	COP9 signalosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005095	Molecular function	GTPase inhibitor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GPS1
Protein name	COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) G protein pathway suppressor 1
Synonyms	CSN1 hCG_1987516 COPS1
Description	FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. .
Accessions	ENST00000583885.5 ENST00000580716.5 ENST00000582327.5 J3KRY5 J3QS88 ENST00000584460.5 Q13098 ENST00000623691.3 A8K070 ENST00000583961.5 ENST00000580627.1 C9JFE4 ENST00000583641.5 A0A096LP07 J3QS84 ENST00000306823.10 [Q13098-4] J3KRE8 ENST00000580723.5 ENST00000581578.5 A0A9L9PXT0 ENST00000581418.5 J3KRJ4 ENST00000583009.4 ENST00000624957.3 J3QQP2 ENST00000578168.1 ENST00000706669.1 ENST00000392358.6 [Q13098-7] J3QLE8 ENST00000585084.5 A0A9L9PX62 J3KTB0 A0A096LPJ3 ENST00000320548.8 J3QLT0 J3QL53 ENST00000706670.1 ENST00000578552.6 [Q13098-5] ENST00000580141.5 ENST00000578392.5 J3KSY1 ENST00000623761.3 J3QQX0 J3KSA5

GPS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review