Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 7 studies | 23% ± 9% | |
CD8-positive, alpha-beta T cell | 7 studies | 22% ± 7% | |
epithelial cell | 5 studies | 34% ± 15% | |
endothelial cell | 4 studies | 23% ± 6% | |
astrocyte | 4 studies | 24% ± 7% | |
CD4-positive, alpha-beta T cell | 4 studies | 26% ± 11% | |
conventional dendritic cell | 3 studies | 20% ± 3% | |
hematopoietic precursor cell | 3 studies | 19% ± 5% | |
ciliated cell | 3 studies | 28% ± 5% | |
erythroblast | 3 studies | 31% ± 12% | |
GABAergic neuron | 3 studies | 42% ± 2% | |
glutamatergic neuron | 3 studies | 57% ± 7% | |
dendritic cell | 3 studies | 24% ± 6% | |
connective tissue cell | 3 studies | 25% ± 6% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 35% ± 15% | |
natural killer cell | 3 studies | 22% ± 4% | |
regulatory T cell | 3 studies | 21% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 671.23 | 180 / 180 | 100% | 6.95 | 430 / 430 |
lung | 100% | 848.46 | 577 / 578 | 100% | 8.90 | 1152 / 1155 |
esophagus | 100% | 973.87 | 1445 / 1445 | 99% | 7.36 | 182 / 183 |
prostate | 100% | 856.71 | 245 / 245 | 99% | 6.39 | 498 / 502 |
uterus | 100% | 817.43 | 170 / 170 | 99% | 11.75 | 455 / 459 |
bladder | 100% | 872.00 | 21 / 21 | 99% | 9.72 | 499 / 504 |
stomach | 100% | 722.75 | 359 / 359 | 99% | 6.64 | 283 / 286 |
breast | 100% | 995.97 | 459 / 459 | 99% | 7.43 | 1106 / 1118 |
brain | 99% | 600.08 | 2621 / 2642 | 100% | 6.55 | 703 / 705 |
intestine | 100% | 767.66 | 966 / 966 | 98% | 7.08 | 516 / 527 |
pancreas | 100% | 545.36 | 328 / 328 | 96% | 4.78 | 170 / 178 |
thymus | 100% | 731.17 | 653 / 653 | 95% | 3.95 | 572 / 605 |
skin | 100% | 1465.41 | 1808 / 1809 | 94% | 6.91 | 446 / 472 |
kidney | 100% | 716.25 | 89 / 89 | 88% | 3.34 | 789 / 901 |
adrenal gland | 100% | 962.27 | 258 / 258 | 87% | 4.58 | 201 / 230 |
liver | 100% | 508.91 | 225 / 226 | 67% | 2.47 | 270 / 406 |
adipose | 100% | 1041.43 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 10.18 | 29 / 29 |
muscle | 100% | 1161.46 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 836.09 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 8.60 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.01 | 1 / 1 |
blood vessel | 100% | 768.58 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 910.42 | 841 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 81% | 3.43 | 65 / 80 |
peripheral blood | 68% | 817.63 | 633 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000434 | Biological process | regulation of protein neddylation |
GO_2000436 | Biological process | positive regulation of protein neddylation |
GO_0006974 | Biological process | DNA damage response |
GO_0045116 | Biological process | protein neddylation |
GO_0001558 | Biological process | regulation of cell growth |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0005819 | Cellular component | spindle |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
GO_0097602 | Molecular function | cullin family protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0032182 | Molecular function | ubiquitin-like protein binding |
Gene name | DCUN1D5 |
Protein name | DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5) DCN1-like protein (Defective in cullin neddylation protein 1-like protein) Defective in cullin neddylation 1 domain containing 5 |
Synonyms | SCCRO5 |
Description | FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) . May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth . . |
Accessions | E9PLH8 ENST00000260247.10 E9PLS2 ENST00000531571.5 ENST00000583974.1 ENST00000527576.5 E9PM04 E9PQV9 ENST00000527779.1 ENST00000529281.5 Q9BTE7 E9PM78 J3QQL8 ENST00000531543.1 H0YCN4 ENST00000529294.5 ENST00000525420.1 ENST00000527260.5 H0YD80 |