Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 12 studies | 35% ± 17% | |
| endothelial cell | 12 studies | 28% ± 12% | |
| oligodendrocyte | 11 studies | 31% ± 11% | |
| oligodendrocyte precursor cell | 10 studies | 26% ± 12% | |
| glutamatergic neuron | 9 studies | 44% ± 26% | |
| adipocyte | 8 studies | 25% ± 6% | |
| GABAergic neuron | 8 studies | 44% ± 23% | |
| fibroblast | 7 studies | 24% ± 10% | |
| neuron | 6 studies | 35% ± 14% | |
| interneuron | 6 studies | 43% ± 25% | |
| smooth muscle cell | 5 studies | 17% ± 1% | |
| macrophage | 4 studies | 23% ± 5% | |
| epithelial cell | 4 studies | 26% ± 12% | |
| endothelial cell of lymphatic vessel | 4 studies | 23% ± 6% | |
| GABAergic interneuron | 3 studies | 30% ± 6% | |
| granule cell | 3 studies | 21% ± 6% | |
| microglial cell | 3 studies | 28% ± 5% | |
| retinal ganglion cell | 3 studies | 32% ± 4% | |
| retina horizontal cell | 3 studies | 26% ± 12% | |
| hepatocyte | 3 studies | 39% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3639.69 | 1445 / 1445 | 100% | 12.85 | 183 / 183 |
| uterus | 100% | 4108.21 | 170 / 170 | 100% | 16.29 | 459 / 459 |
| bladder | 100% | 4671.05 | 21 / 21 | 100% | 13.25 | 503 / 504 |
| brain | 100% | 2980.64 | 2636 / 2642 | 100% | 23.29 | 705 / 705 |
| liver | 100% | 3048.68 | 226 / 226 | 100% | 13.61 | 405 / 406 |
| lung | 100% | 2701.28 | 577 / 578 | 100% | 14.17 | 1154 / 1155 |
| breast | 100% | 3093.80 | 459 / 459 | 100% | 18.14 | 1114 / 1118 |
| adrenal gland | 100% | 4218.19 | 258 / 258 | 100% | 20.58 | 229 / 230 |
| kidney | 100% | 2605.17 | 89 / 89 | 100% | 18.92 | 897 / 901 |
| thymus | 100% | 3786.64 | 653 / 653 | 100% | 14.21 | 602 / 605 |
| prostate | 100% | 3377.92 | 245 / 245 | 99% | 11.98 | 499 / 502 |
| intestine | 100% | 3596.01 | 966 / 966 | 98% | 10.54 | 518 / 527 |
| pancreas | 99% | 1407.36 | 326 / 328 | 99% | 13.96 | 176 / 178 |
| stomach | 100% | 3025.84 | 359 / 359 | 98% | 10.60 | 281 / 286 |
| ovary | 100% | 4724.00 | 180 / 180 | 98% | 9.87 | 421 / 430 |
| skin | 100% | 2405.81 | 1804 / 1809 | 93% | 13.98 | 441 / 472 |
| blood vessel | 100% | 4315.32 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2658.21 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.22 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.90 | 1 / 1 |
| adipose | 100% | 3180.69 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1752.94 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1875.07 | 840 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 6.02 | 25 / 29 |
| eye | 0% | 0 | 0 / 0 | 63% | 5.59 | 50 / 80 |
| peripheral blood | 28% | 617.49 | 263 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_2000436 | Biological process | positive regulation of protein neddylation |
| GO_0045116 | Biological process | protein neddylation |
| GO_0000151 | Cellular component | ubiquitin ligase complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0097602 | Molecular function | cullin family protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0032182 | Molecular function | ubiquitin-like protein binding |
| GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
| Gene name | DCUN1D4 |
| Protein name | Defective in cullin neddylation 1 domain containing 4 DCN1-like protein (Defective in cullin neddylation protein 1-like protein) DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4) |
| Synonyms | hCG_21420 KIAA0276 |
| Description | FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). . |
| Accessions | ENST00000506673.5 D6RIY3 ENST00000505403.5 ENST00000334635.10 [Q92564-1] ENST00000507741.5 Q92564 H0Y907 ENST00000477560.5 D6RDV8 ENST00000381441.7 [Q92564-2] ENST00000451288.6 [Q92564-3] ENST00000509376.5 H0Y9C5 ENST00000510808.1 ENST00000502930.5 D6RGX7 D6RB33 H0YA35 D6RCB7 ENST00000505634.5 ENST00000512199.5 |