AKTIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032092Biological processpositive regulation of protein binding
GO_0007040Biological processlysosome organization
GO_0006915Biological processapoptotic process
GO_1905719Biological processprotein localization to perinuclear region of cytoplasm
GO_0015031Biological processprotein transport
GO_0045022Biological processearly endosome to late endosome transport
GO_0045116Biological processprotein neddylation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0008333Biological processendosome to lysosome transport
GO_0007032Biological processendosome organization
GO_0070695Cellular componentFHF complex
GO_0030897Cellular componentHOPS complex
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0019788Molecular functionNEDD8 transferase activity
GO_0019787Molecular functionubiquitin-like protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKTIP
Protein nameAKT-interacting protein
AKT interacting protein
AKT-interacting protein (Ft1) (Fused toes protein homolog)
SynonymsFTS
DescriptionFUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex) . The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell . .

AccessionsENST00000300245.8 [Q9H8T0-2]
H3BRV2
ENST00000570041.1
ENST00000564497.1
Q9H8T0
ENST00000394657.12 [Q9H8T0-1]
H3BVH0
ENST00000568022.5
ENST00000565408.5
ENST00000563928.5
H3BNB8
ENST00000568596.5
ENST00000570004.5 [Q9H8T0-1]
H3BRT7
H3BM79
H3BSX7