TRIM40 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM40 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	55%	150.96	532 / 966	60%	2.26	315 / 527
stomach	32%	14.09	114 / 359	54%	2.02	154 / 286
kidney	56%	17.65	50 / 89	0%	0.01	3 / 901
lung	32%	5.16	184 / 578	9%	0.32	100 / 1155
liver	27%	97.26	61 / 226	10%	0.34	42 / 406
esophagus	2%	0.84	31 / 1445	29%	1.52	53 / 183
peripheral blood	29%	3.50	270 / 929	0%	0	0 / 0
spleen	17%	1.88	42 / 241	0%	0	0 / 0
bladder	0%	0	0 / 21	17%	0.53	84 / 504
pancreas	1%	0.12	3 / 328	10%	0.45	17 / 178
skin	7%	0.61	118 / 1809	0%	0	0 / 472
prostate	4%	0.41	9 / 245	0%	0	0 / 502
uterus	0%	0	0 / 170	3%	0.10	16 / 459
thymus	2%	0.14	11 / 653	0%	0	0 / 605
breast	1%	0.45	6 / 459	0%	0.00	1 / 1118
adrenal gland	1%	0.07	3 / 258	0%	0	0 / 230
brain	1%	0.15	29 / 2642	0%	0	0 / 705
adipose	1%	0.10	9 / 1204	0%	0	0 / 0
heart	0%	0.05	4 / 861	0%	0	0 / 0
blood vessel	0%	0.04	3 / 1335	0%	0	0 / 0
muscle	0%	0.01	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0016567	Biological process	protein ubiquitination
GO_1900181	Biological process	negative regulation of protein localization to nucleus
GO_0045116	Biological process	protein neddylation
GO_0032088	Biological process	negative regulation of NF-kappaB transcription factor activity
GO_0045087	Biological process	innate immune response
GO_0030308	Biological process	negative regulation of cell growth
GO_1901223	Biological process	negative regulation of non-canonical NF-kappaB signal transduction
GO_0008385	Cellular component	IkappaB kinase complex
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

Gene name	TRIM40
Protein name	TRIM40 E3 ubiquitin ligase TRIM40 (EC 2.3.2.27) (Probable E3 NEDD8-protein ligase) (RING finger protein 35) E3 ubiquitin ligase TRIM40
Synonyms	RNF35
Description	FUNCTION: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response . Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation . Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation . .
Accessions	ENST00000429471.6 [Q6P9F5-2] Q6P9F5 ENST00000418267.6 ENST00000552119.2 [Q6P9F5-1] ENST00000396581.6 [Q6P9F5-1] ENST00000547289.2 [Q6P9F5-1] ENST00000549728.2 [Q6P9F5-1] ENST00000616351.1 [Q6P9F5-1] ENST00000376724.6 [Q6P9F5-1] ENST00000456884.6 ENST00000445004.6 ENST00000421981.6 [Q6P9F5-2] ENST00000434151.5 [Q6P9F5-1] ENST00000437563.5 [Q6P9F5-1] A0A0G2JIV5 ENST00000400651.7 [Q6P9F5-2] ENST00000614405.1 A0A0G2JK97 ENST00000430485.5 A0A0G2JMU7 ENST00000431397.5 ENST00000618891.1 ENST00000433713.5 [Q6P9F5-1] A0A140T9D5 ENST00000307859.4 [Q6P9F5-2] ENST00000548672.2 ENST00000383610.6 [Q6P9F5-1] ENST00000425845.5 ENST00000436951.6 [Q6P9F5-2]

TRIM40 report