Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 24% ± 5% | |
natural killer cell | 6 studies | 20% ± 4% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 6 studies | 18% ± 4% | |
epithelial cell | 6 studies | 34% ± 12% | |
astrocyte | 6 studies | 26% ± 5% | |
CD4-positive, alpha-beta T cell | 5 studies | 23% ± 5% | |
CD8-positive, alpha-beta T cell | 5 studies | 20% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 18% ± 3% | |
ciliated cell | 5 studies | 26% ± 5% | |
GABAergic neuron | 5 studies | 38% ± 16% | |
pericyte | 4 studies | 18% ± 3% | |
glutamatergic neuron | 4 studies | 54% ± 15% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 10% | |
interneuron | 4 studies | 38% ± 20% | |
oligodendrocyte | 4 studies | 25% ± 3% | |
B cell | 3 studies | 20% ± 4% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
connective tissue cell | 3 studies | 20% ± 4% | |
fibroblast | 3 studies | 29% ± 3% | |
Mueller cell | 3 studies | 19% ± 3% | |
intestinal crypt stem cell | 3 studies | 18% ± 2% | |
basal cell | 3 studies | 35% ± 2% | |
neuron | 3 studies | 35% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2143.27 | 1445 / 1445 | 100% | 34.83 | 183 / 183 |
uterus | 100% | 2572.94 | 170 / 170 | 100% | 33.83 | 459 / 459 |
brain | 100% | 2137.27 | 2641 / 2642 | 100% | 40.04 | 705 / 705 |
breast | 100% | 2298.59 | 459 / 459 | 100% | 32.97 | 1116 / 1118 |
bladder | 100% | 2100.95 | 21 / 21 | 100% | 38.85 | 503 / 504 |
stomach | 100% | 1617.96 | 359 / 359 | 100% | 35.90 | 285 / 286 |
intestine | 100% | 2187.75 | 966 / 966 | 100% | 37.82 | 525 / 527 |
prostate | 100% | 2036.41 | 245 / 245 | 100% | 26.57 | 500 / 502 |
ovary | 100% | 2625.91 | 180 / 180 | 100% | 22.43 | 428 / 430 |
lung | 99% | 1649.41 | 575 / 578 | 100% | 33.70 | 1155 / 1155 |
thymus | 100% | 2204.40 | 653 / 653 | 99% | 34.67 | 601 / 605 |
adrenal gland | 100% | 2196.17 | 258 / 258 | 99% | 30.52 | 228 / 230 |
kidney | 100% | 1579.89 | 89 / 89 | 99% | 21.30 | 891 / 901 |
pancreas | 99% | 1315.90 | 326 / 328 | 99% | 24.49 | 176 / 178 |
skin | 100% | 2605.47 | 1809 / 1809 | 98% | 31.59 | 461 / 472 |
liver | 100% | 972.08 | 226 / 226 | 97% | 16.46 | 394 / 406 |
adipose | 100% | 2099.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1936.91 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 27.41 | 29 / 29 |
spleen | 100% | 1648.17 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 25.12 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 22.97 | 1 / 1 |
muscle | 100% | 1775.42 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1293.09 | 840 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 18.59 | 74 / 80 |
peripheral blood | 46% | 936.54 | 428 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0007165 | Biological process | signal transduction |
GO_0006974 | Biological process | DNA damage response |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0043523 | Biological process | regulation of neuron apoptotic process |
GO_0051402 | Biological process | neuron apoptotic process |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0045116 | Biological process | protein neddylation |
GO_0033314 | Biological process | mitotic DNA replication checkpoint signaling |
GO_0005886 | Cellular component | plasma membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004839 | Molecular function | ubiquitin activating enzyme activity |
GO_0019781 | Molecular function | NEDD8 activating enzyme activity |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0005515 | Molecular function | protein binding |
Gene name | NAE1 |
Protein name | NEDD8 activating enzyme E1 subunit 1 NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1) Alternative protein NAE1 |
Synonyms | APPBP1 HPP1 |
Description | FUNCTION: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. . |
Accessions | J3QRA5 ENST00000567743.5 H3BQ16 ENST00000563185.6 J3KTE3 ENST00000566663.5 H3BMN8 J3QLH4 ENST00000562428.6 Q13564 ENST00000359087.8 [Q13564-4] ENST00000394074.6 [Q13564-3] ENST00000290810.8 [Q13564-1] H3BQW6 J3KRK3 H3BMR3 ENST00000379463.6 [Q13564-2] ENST00000569348.5 ENST00000561579.6 L8E934 H3BS69 H3BSS8 ENST00000569388.5 ENST00000563253.5 ENST00000565535.5 ENST00000566336.5 |