NAE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0007165Biological processsignal transduction
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0043523Biological processregulation of neuron apoptotic process
GO_0051402Biological processneuron apoptotic process
GO_0042981Biological processregulation of apoptotic process
GO_0045116Biological processprotein neddylation
GO_0033314Biological processmitotic DNA replication checkpoint signaling
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004839Molecular functionubiquitin activating enzyme activity
GO_0019781Molecular functionNEDD8 activating enzyme activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNAE1
Protein nameNEDD8 activating enzyme E1 subunit 1
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Alternative protein NAE1
SynonymsAPPBP1
HPP1
DescriptionFUNCTION: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. .

AccessionsJ3QRA5
ENST00000567743.5
H3BQ16
ENST00000563185.6
J3KTE3
ENST00000566663.5
H3BMN8
J3QLH4
ENST00000562428.6
Q13564
ENST00000359087.8 [Q13564-4]
ENST00000394074.6 [Q13564-3]
ENST00000290810.8 [Q13564-1]
H3BQW6
J3KRK3
H3BMR3
ENST00000379463.6 [Q13564-2]
ENST00000569348.5
ENST00000561579.6
L8E934
H3BS69
H3BSS8
ENST00000569388.5
ENST00000563253.5
ENST00000565535.5
ENST00000566336.5