Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 22% ± 7% | |
fibroblast | 6 studies | 24% ± 7% | |
epithelial cell | 5 studies | 32% ± 11% | |
astrocyte | 5 studies | 25% ± 5% | |
connective tissue cell | 4 studies | 23% ± 5% | |
ciliated cell | 4 studies | 23% ± 5% | |
GABAergic neuron | 4 studies | 38% ± 13% | |
glutamatergic neuron | 4 studies | 48% ± 16% | |
basal cell | 4 studies | 24% ± 8% | |
neuron | 4 studies | 27% ± 10% | |
oligodendrocyte | 4 studies | 20% ± 2% | |
pancreatic A cell | 3 studies | 23% ± 5% | |
type B pancreatic cell | 3 studies | 30% ± 10% | |
myofibroblast cell | 3 studies | 22% ± 2% | |
pericyte | 3 studies | 21% ± 5% | |
smooth muscle cell | 3 studies | 21% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 3% | |
dendritic cell | 3 studies | 29% ± 10% | |
natural killer cell | 3 studies | 17% ± 1% | |
interneuron | 3 studies | 39% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1905.26 | 1445 / 1445 | 100% | 30.85 | 183 / 183 |
ovary | 100% | 2012.52 | 180 / 180 | 100% | 23.97 | 430 / 430 |
stomach | 100% | 1453.94 | 359 / 359 | 100% | 27.51 | 286 / 286 |
breast | 100% | 2026.44 | 459 / 459 | 100% | 43.26 | 1116 / 1118 |
prostate | 100% | 1759.36 | 245 / 245 | 100% | 36.31 | 501 / 502 |
intestine | 100% | 1945.62 | 966 / 966 | 100% | 28.52 | 525 / 527 |
brain | 100% | 2288.73 | 2631 / 2642 | 100% | 48.80 | 705 / 705 |
uterus | 100% | 2245.29 | 170 / 170 | 100% | 34.45 | 457 / 459 |
thymus | 100% | 1932.91 | 652 / 653 | 100% | 43.82 | 602 / 605 |
lung | 99% | 1590.26 | 574 / 578 | 100% | 32.40 | 1155 / 1155 |
bladder | 100% | 2079.33 | 21 / 21 | 99% | 29.99 | 497 / 504 |
pancreas | 98% | 980.81 | 323 / 328 | 100% | 27.41 | 178 / 178 |
kidney | 100% | 1830.28 | 89 / 89 | 98% | 28.22 | 880 / 901 |
skin | 100% | 2341.69 | 1809 / 1809 | 97% | 33.50 | 459 / 472 |
adrenal gland | 100% | 2731.10 | 258 / 258 | 97% | 45.26 | 223 / 230 |
liver | 94% | 788.55 | 213 / 226 | 96% | 16.03 | 390 / 406 |
adipose | 100% | 1971.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2393.75 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 35.51 | 29 / 29 |
muscle | 100% | 4142.15 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1771.16 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 38.38 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.57 | 1 / 1 |
heart | 97% | 2324.56 | 832 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 24.06 | 76 / 80 |
peripheral blood | 79% | 1117.53 | 737 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000434 | Biological process | regulation of protein neddylation |
GO_0045116 | Biological process | protein neddylation |
GO_0000338 | Biological process | protein deneddylation |
GO_0016607 | Cellular component | nuclear speck |
GO_0030054 | Cellular component | cell junction |
GO_0008180 | Cellular component | COP9 signalosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0008021 | Cellular component | synaptic vesicle |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0019784 | Molecular function | deNEDDylase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | COPS4 |
Protein name | COP9 signalosome complex subunit 4 COP9 signalosome subunit 4 COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) |
Synonyms | CSN4 |
Description | FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. . |
Accessions | ENST00000503682.5 ENST00000507376.1 ENST00000511653.1 A0A0S2Z5H7 D6RAX7 Q9BT78 D6RFN0 ENST00000509317.5 D6RD63 D6REK7 ENST00000509093.5 [Q9BT78-2] ENST00000264389.7 [Q9BT78-1] |