NEDD8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	37 studies	44% ± 13%	Explore
B cell	34 studies	38% ± 14%	Explore
fibroblast	34 studies	46% ± 18%	Explore
CD8-positive, alpha-beta T cell	34 studies	42% ± 18%	Explore
macrophage	33 studies	45% ± 17%	Explore
endothelial cell	32 studies	48% ± 19%	Explore
CD4-positive, alpha-beta T cell	31 studies	40% ± 16%	Explore
T cell	28 studies	41% ± 14%	Explore
conventional dendritic cell	27 studies	49% ± 16%	Explore
pericyte	26 studies	49% ± 16%	Explore
classical monocyte	25 studies	45% ± 16%	Explore
smooth muscle cell	24 studies	47% ± 16%	Explore
non-classical monocyte	23 studies	51% ± 15%	Explore
plasmacytoid dendritic cell	23 studies	53% ± 16%	Explore
regulatory T cell	22 studies	42% ± 14%	Explore
dendritic cell	21 studies	43% ± 22%	Explore
epithelial cell	21 studies	48% ± 22%	Explore
memory B cell	19 studies	32% ± 9%	Explore
basal cell	19 studies	46% ± 21%	Explore
mast cell	18 studies	40% ± 13%	Explore
monocyte	18 studies	46% ± 15%	Explore
mature NK T cell	18 studies	39% ± 11%	Explore
connective tissue cell	18 studies	47% ± 20%	Explore
endothelial cell of lymphatic vessel	17 studies	59% ± 15%	Explore
naive B cell	17 studies	30% ± 8%	Explore
gamma-delta T cell	17 studies	42% ± 14%	Explore
ciliated cell	16 studies	54% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	34% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	44% ± 11%	Explore
mucosal invariant T cell	14 studies	33% ± 9%	Explore
plasma cell	13 studies	47% ± 13%	Explore
myofibroblast cell	13 studies	48% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	44% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	39% ± 12%	Explore
capillary endothelial cell	12 studies	38% ± 8%	Explore
myeloid cell	12 studies	43% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	39% ± 18%	Explore
secretory cell	11 studies	41% ± 20%	Explore
vein endothelial cell	11 studies	46% ± 13%	Explore
endothelial cell of vascular tree	11 studies	42% ± 12%	Explore
plasmablast	10 studies	50% ± 24%	Explore
progenitor cell	10 studies	52% ± 18%	Explore
endothelial cell of artery	10 studies	44% ± 15%	Explore
goblet cell	10 studies	38% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	44% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	42% ± 13%	Explore
abnormal cell	9 studies	45% ± 15%	Explore
mesothelial cell	9 studies	55% ± 20%	Explore
leukocyte	8 studies	43% ± 16%	Explore
T follicular helper cell	8 studies	39% ± 7%	Explore
type I pneumocyte	7 studies	51% ± 12%	Explore
club cell	7 studies	42% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	47% ± 17%	Explore
type II pneumocyte	6 studies	51% ± 18%	Explore
respiratory goblet cell	6 studies	34% ± 21%	Explore
platelet	6 studies	20% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	55% ± 16%	Explore
mononuclear phagocyte	6 studies	50% ± 21%	Explore
kidney loop of Henle epithelial cell	6 studies	43% ± 8%	Explore
neutrophil	6 studies	34% ± 8%	Explore
renal alpha-intercalated cell	6 studies	63% ± 9%	Explore
enterocyte	6 studies	39% ± 13%	Explore
transit amplifying cell	6 studies	35% ± 15%	Explore
precursor B cell	6 studies	37% ± 13%	Explore
innate lymphoid cell	6 studies	38% ± 4%	Explore
neuron	6 studies	50% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	47% ± 21%	Explore
alveolar macrophage	5 studies	54% ± 10%	Explore
hematopoietic precursor cell	5 studies	52% ± 27%	Explore
exhausted T cell	5 studies	57% ± 16%	Explore
ionocyte	5 studies	38% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	56% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	59% ± 16%	Explore
enteroendocrine cell	5 studies	54% ± 22%	Explore
intestinal crypt stem cell	5 studies	37% ± 16%	Explore
astrocyte	5 studies	37% ± 17%	Explore
erythrocyte	5 studies	45% ± 19%	Explore
intermediate monocyte	5 studies	61% ± 16%	Explore
granulocyte	5 studies	40% ± 18%	Explore
deuterosomal cell	4 studies	37% ± 10%	Explore
pancreatic A cell	4 studies	68% ± 15%	Explore
type B pancreatic cell	4 studies	64% ± 17%	Explore
glomerular endothelial cell	4 studies	42% ± 13%	Explore
erythroblast	4 studies	48% ± 25%	Explore
IgG plasma cell	4 studies	25% ± 10%	Explore
retinal ganglion cell	4 studies	80% ± 22%	Explore
retinal cone cell	4 studies	56% ± 25%	Explore
retinal rod cell	4 studies	34% ± 12%	Explore
hematopoietic stem cell	4 studies	49% ± 9%	Explore
pro-B cell	4 studies	39% ± 10%	Explore
brush cell	4 studies	32% ± 19%	Explore
immature B cell	4 studies	47% ± 22%	Explore
amacrine cell	4 studies	50% ± 18%	Explore
retina horizontal cell	4 studies	47% ± 19%	Explore
microglial cell	4 studies	37% ± 19%	Explore
adventitial cell	4 studies	36% ± 5%	Explore
mucus secreting cell	4 studies	43% ± 21%	Explore
CD4-positive helper T cell	4 studies	29% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	45% ± 12%	Explore
oligodendrocyte precursor cell	4 studies	35% ± 15%	Explore
group 3 innate lymphoid cell	4 studies	45% ± 15%	Explore
T-helper 17 cell	4 studies	55% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	39% ± 6%	Explore
double negative thymocyte	4 studies	49% ± 18%	Explore
duct epithelial cell	3 studies	38% ± 2%	Explore
squamous epithelial cell	3 studies	40% ± 26%	Explore
podocyte	3 studies	65% ± 8%	Explore
neural crest cell	3 studies	64% ± 5%	Explore
retinal bipolar neuron	3 studies	51% ± 22%	Explore
OFF-bipolar cell	3 studies	53% ± 33%	Explore
ON-bipolar cell	3 studies	55% ± 33%	Explore
GABAergic amacrine cell	3 studies	25% ± 11%	Explore
renal principal cell	3 studies	52% ± 1%	Explore
extravillous trophoblast	3 studies	74% ± 14%	Explore
placental villous trophoblast	3 studies	79% ± 14%	Explore
lymphocyte	3 studies	59% ± 8%	Explore
megakaryocyte	3 studies	34% ± 5%	Explore
neuroendocrine cell	3 studies	45% ± 9%	Explore
serous secreting cell	3 studies	48% ± 15%	Explore
tissue-resident macrophage	3 studies	31% ± 17%	Explore
intraepithelial lymphocyte	3 studies	48% ± 4%	Explore
Mueller cell	3 studies	43% ± 10%	Explore
rod bipolar cell	3 studies	43% ± 17%	Explore
muscle cell	3 studies	37% ± 26%	Explore
oligodendrocyte	3 studies	18% ± 2%	Explore
germinal center B cell	3 studies	47% ± 5%	Explore
myoepithelial cell	3 studies	43% ± 21%	Explore
luminal cell of prostate epithelium	3 studies	37% ± 9%	Explore
pancreatic ductal cell	3 studies	57% ± 3%	Explore
granulocyte monocyte progenitor cell	3 studies	56% ± 29%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	55% ± 30%	Explore
glial cell	3 studies	45% ± 25%	Explore
hepatocyte	3 studies	57% ± 30%	Explore
keratinocyte	3 studies	53% ± 4%	Explore
T-helper 1 cell	3 studies	55% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	39% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	37% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	34% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	46% ± 18%	Explore
peripheral blood	18 studies	43% ± 14%	Explore
intestine	13 studies	37% ± 19%	Explore
kidney	9 studies	43% ± 14%	Explore
eye	8 studies	36% ± 14%	Explore
brain	7 studies	29% ± 8%	Explore
lymph node	6 studies	37% ± 15%	Explore
pancreas	5 studies	52% ± 25%	Explore
bone marrow	5 studies	31% ± 13%	Explore
liver	5 studies	49% ± 21%	Explore
placenta	4 studies	58% ± 27%	Explore
uterus	4 studies	60% ± 15%	Explore
prostate	4 studies	27% ± 9%	Explore
breast	4 studies	40% ± 10%	Explore
adrenal gland	3 studies	38% ± 12%	Explore
esophagus	3 studies	52% ± 28%	Explore
skin	3 studies	42% ± 12%	Explore
thymus	3 studies	58% ± 26%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4498.76	21 / 21	100%	29.50	504 / 504
brain	100%	5566.75	2642 / 2642	100%	24.09	705 / 705
esophagus	100%	4784.15	1445 / 1445	100%	22.22	183 / 183
liver	100%	2800.25	226 / 226	100%	19.75	406 / 406
ovary	100%	3918.53	180 / 180	100%	33.79	430 / 430
skin	100%	5878.14	1809 / 1809	100%	21.55	472 / 472
stomach	100%	3412.99	359 / 359	100%	23.43	286 / 286
thymus	100%	4316.09	653 / 653	100%	25.17	605 / 605
uterus	100%	4310.55	170 / 170	100%	31.19	459 / 459
kidney	100%	5189.17	89 / 89	100%	17.70	900 / 901
intestine	100%	4419.60	966 / 966	100%	25.73	526 / 527
prostate	100%	4146.78	245 / 245	100%	21.89	501 / 502
lung	100%	4418.15	576 / 578	100%	23.28	1155 / 1155
breast	100%	4566.10	459 / 459	100%	26.27	1114 / 1118
adrenal gland	100%	6224.76	258 / 258	100%	27.37	229 / 230
pancreas	98%	1853.42	323 / 328	99%	23.48	177 / 178
adipose	100%	4781.84	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5084.58	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	40.78	29 / 29
muscle	100%	4556.74	803 / 803	0%	0	0 / 0
spleen	100%	4717.36	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	25.50	45 / 45
ureter	0%	0	0 / 0	100%	23.69	1 / 1
heart	99%	4755.96	853 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	21.01	79 / 80
peripheral blood	99%	4347.43	917 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009653	Biological process	anatomical structure morphogenesis
GO_0019941	Biological process	modification-dependent protein catabolic process
GO_0016567	Biological process	protein ubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0008104	Biological process	protein localization
GO_0045116	Biological process	protein neddylation
GO_0030162	Biological process	regulation of proteolysis
GO_0036211	Biological process	protein modification process
GO_0006508	Biological process	proteolysis
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0031386	Molecular function	protein tag activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NEDD8
Protein name	NEDD8 ubiquitin like modifier NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8) Neural cell expressed developmentally down-regulated protein 8
Synonyms
Description	FUNCTION: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 . Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins . Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity . Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M . .
Accessions	ENST00000524927.1 Q96L81 ENST00000396828.8 Q15843 ENST00000643069.2 F8VSA6 ENST00000250495.10

NEDD8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review