COPS5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903894Biological processregulation of IRE1-mediated unfolded protein response
GO_0046328Biological processregulation of JNK cascade
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0000338Biological processprotein deneddylation
GO_0006412Biological processtranslation
GO_0006413Biological processtranslational initiation
GO_0043687Biological processpost-translational protein modification
GO_2000434Biological processregulation of protein neddylation
GO_0045116Biological processprotein neddylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006508Biological processproteolysis
GO_1990182Biological processexosomal secretion
GO_0051726Biological processregulation of cell cycle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0008180Cellular componentCOP9 signalosome
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005852Cellular componenteukaryotic translation initiation factor 3 complex
GO_0005634Cellular componentnucleus
GO_0140492Molecular functionmetal-dependent deubiquitinase activity
GO_0019899Molecular functionenzyme binding
GO_0008237Molecular functionmetallopeptidase activity
GO_0003743Molecular functiontranslation initiation factor activity
GO_0035718Molecular functionmacrophage migration inhibitory factor binding
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0019784Molecular functiondeNEDDylase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOPS5
Protein nameCOP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), isoform CRA_a (Testis secretory sperm-binding protein Li 231m)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
COP9 signalosome subunit 5
SynonymshCG_27806
CSN5
JAB1
DescriptionFUNCTION: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. .

AccessionsENST00000518747.1
Q92905
ENST00000357849.9
E5RG35
ENST00000518374.5
E5RHF2
E5RK55
ENST00000517406.1
A0A024R7W9
ENST00000523890.5
ENST00000517736.5
E5RHH5
E5RFS1