Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 10 studies | 34% ± 15% | |
oligodendrocyte | 9 studies | 29% ± 8% | |
endothelial cell | 8 studies | 24% ± 4% | |
epithelial cell | 6 studies | 31% ± 12% | |
glutamatergic neuron | 5 studies | 45% ± 23% | |
macrophage | 5 studies | 21% ± 5% | |
fibroblast | 4 studies | 21% ± 5% | |
GABAergic neuron | 4 studies | 41% ± 15% | |
microglial cell | 4 studies | 23% ± 5% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 8% | |
interneuron | 4 studies | 35% ± 20% | |
ciliated cell | 3 studies | 23% ± 1% | |
basal cell | 3 studies | 26% ± 2% | |
neuron | 3 studies | 30% ± 10% | |
hepatocyte | 3 studies | 37% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1805.67 | 2642 / 2642 | 100% | 16.62 | 705 / 705 |
esophagus | 100% | 1825.90 | 1445 / 1445 | 100% | 23.46 | 183 / 183 |
ovary | 100% | 1382.34 | 180 / 180 | 100% | 17.46 | 430 / 430 |
lung | 100% | 1527.48 | 577 / 578 | 100% | 27.37 | 1155 / 1155 |
breast | 100% | 1599.38 | 459 / 459 | 100% | 19.43 | 1116 / 1118 |
prostate | 100% | 1583.74 | 245 / 245 | 100% | 14.42 | 501 / 502 |
uterus | 100% | 1624.81 | 170 / 170 | 100% | 20.02 | 457 / 459 |
thymus | 100% | 1695.06 | 653 / 653 | 99% | 11.99 | 599 / 605 |
bladder | 100% | 2127.95 | 21 / 21 | 99% | 16.15 | 499 / 504 |
kidney | 100% | 1319.06 | 89 / 89 | 98% | 11.61 | 883 / 901 |
pancreas | 99% | 802.26 | 325 / 328 | 99% | 12.29 | 176 / 178 |
stomach | 100% | 1285.70 | 359 / 359 | 98% | 13.23 | 279 / 286 |
intestine | 100% | 1759.90 | 966 / 966 | 97% | 12.44 | 513 / 527 |
liver | 100% | 1556.52 | 226 / 226 | 97% | 10.60 | 394 / 406 |
skin | 100% | 1716.73 | 1807 / 1809 | 90% | 10.04 | 423 / 472 |
adrenal gland | 100% | 1711.26 | 258 / 258 | 87% | 5.64 | 201 / 230 |
blood vessel | 100% | 1603.33 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 12.69 | 29 / 29 |
muscle | 100% | 3090.77 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1528.56 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 23.03 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.78 | 1 / 1 |
adipose | 100% | 1631.80 | 1203 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 1381.45 | 905 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 953.98 | 833 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 36% | 1.69 | 29 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000434 | Biological process | regulation of protein neddylation |
GO_2000436 | Biological process | positive regulation of protein neddylation |
GO_0045116 | Biological process | protein neddylation |
GO_0031396 | Biological process | regulation of protein ubiquitination |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
GO_0097602 | Molecular function | cullin family protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0032182 | Molecular function | ubiquitin-like protein binding |
Gene name | DCUN1D1 |
Protein name | DCN1-like protein (Defective in cullin neddylation protein 1-like protein) DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) Defective in cullin neddylation 1 domain containing 1 |
Synonyms | RP42 DCN1 DCUN1L1 SCCRO hCG_17206 |
Description | FUNCTION: Part of an E3 ubiquitin ligase complex for neddylation . Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes . Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity . Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). . |
Accessions | C9JVE2 ENST00000487822.5 ENST00000492563.1 ENST00000292782.9 C9JRU6 ENST00000460412.6 F8WC32 ENST00000466812.1 C9J8R4 ENST00000497606.5 ENST00000632685.1 C9J0B2 Q96GG9 ENST00000469954.5 |