DCUN1D1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000434Biological processregulation of protein neddylation
GO_2000436Biological processpositive regulation of protein neddylation
GO_0045116Biological processprotein neddylation
GO_0031396Biological processregulation of protein ubiquitination
GO_0000151Cellular componentubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0031624Molecular functionubiquitin conjugating enzyme binding
GO_0097602Molecular functioncullin family protein binding
GO_0005515Molecular functionprotein binding
GO_0032182Molecular functionubiquitin-like protein binding

IV. Literature review

[source]
Gene nameDCUN1D1
Protein nameDCN1-like protein (Defective in cullin neddylation protein 1-like protein)
DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
Defective in cullin neddylation 1 domain containing 1
SynonymsRP42
DCN1
DCUN1L1
SCCRO
hCG_17206
DescriptionFUNCTION: Part of an E3 ubiquitin ligase complex for neddylation . Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes . Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity . Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). .

AccessionsC9JVE2
ENST00000487822.5
ENST00000492563.1
ENST00000292782.9
C9JRU6
ENST00000460412.6
F8WC32
ENST00000466812.1
C9J8R4
ENST00000497606.5
ENST00000632685.1
C9J0B2
Q96GG9
ENST00000469954.5