COPS2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	16 studies	24% ± 7%	Explore
fibroblast	16 studies	25% ± 7%	Explore
smooth muscle cell	13 studies	22% ± 4%	Explore
natural killer cell	11 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	11 studies	20% ± 4%	Explore
regulatory T cell	11 studies	20% ± 4%	Explore
pericyte	11 studies	23% ± 4%	Explore
B cell	10 studies	21% ± 4%	Explore
CD4-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
naive B cell	8 studies	20% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	19% ± 4%	Explore
myofibroblast cell	8 studies	20% ± 4%	Explore
classical monocyte	7 studies	23% ± 7%	Explore
mucosal invariant T cell	7 studies	24% ± 5%	Explore
epithelial cell	7 studies	38% ± 23%	Explore
basal cell	7 studies	29% ± 10%	Explore
gamma-delta T cell	7 studies	25% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	23% ± 4%	Explore
connective tissue cell	6 studies	22% ± 4%	Explore
memory B cell	6 studies	20% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 8%	Explore
oligodendrocyte	6 studies	26% ± 7%	Explore
mast cell	5 studies	19% ± 2%	Explore
endothelial cell of lymphatic vessel	5 studies	21% ± 3%	Explore
non-classical monocyte	5 studies	29% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 6%	Explore
endothelial cell of vascular tree	5 studies	18% ± 2%	Explore
neuron	5 studies	26% ± 13%	Explore
macrophage	5 studies	20% ± 3%	Explore
T cell	4 studies	21% ± 3%	Explore
conventional dendritic cell	4 studies	31% ± 11%	Explore
mature NK T cell	4 studies	18% ± 3%	Explore
ciliated cell	4 studies	29% ± 11%	Explore
abnormal cell	4 studies	21% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
leukocyte	3 studies	18% ± 2%	Explore
plasmablast	3 studies	37% ± 15%	Explore
neural crest cell	3 studies	17% ± 1%	Explore
retina horizontal cell	3 studies	19% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	26% ± 8%	Explore
vein endothelial cell	3 studies	19% ± 3%	Explore
GABAergic neuron	3 studies	48% ± 5%	Explore
glutamatergic neuron	3 studies	59% ± 4%	Explore
dendritic cell	3 studies	40% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	33% ± 22%	Explore
T follicular helper cell	3 studies	21% ± 4%	Explore
hematopoietic stem cell	3 studies	17% ± 0%	Explore
plasmacytoid dendritic cell	3 studies	25% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	26% ± 2%	Explore
double negative thymocyte	3 studies	32% ± 8%	Explore
astrocyte	3 studies	27% ± 6%	Explore
interneuron	3 studies	42% ± 20%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	24% ± 5%	Explore
lung	8 studies	22% ± 6%	Explore
brain	5 studies	38% ± 13%	Explore
uterus	3 studies	28% ± 13%	Explore
intestine	3 studies	25% ± 7%	Explore
liver	3 studies	28% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4453.34	459 / 459	100%	40.64	1118 / 1118
esophagus	100%	3880.94	1445 / 1445	100%	33.62	183 / 183
ovary	100%	4672.66	180 / 180	100%	22.56	430 / 430
prostate	100%	3379.79	245 / 245	100%	32.91	502 / 502
lung	100%	3438.29	577 / 578	100%	32.66	1155 / 1155
adrenal gland	100%	3991.56	258 / 258	100%	32.50	229 / 230
uterus	100%	4301.41	170 / 170	100%	33.03	457 / 459
thymus	100%	3202.08	653 / 653	100%	36.20	602 / 605
bladder	100%	4260.81	21 / 21	99%	28.00	501 / 504
brain	99%	2848.34	2624 / 2642	100%	29.08	705 / 705
stomach	100%	2940.51	359 / 359	99%	25.75	284 / 286
liver	100%	1980.37	226 / 226	99%	18.11	403 / 406
kidney	100%	2835.48	89 / 89	99%	32.01	894 / 901
pancreas	99%	2318.01	326 / 328	99%	26.31	177 / 178
intestine	100%	3982.22	966 / 966	98%	27.42	519 / 527
skin	100%	4381.03	1809 / 1809	96%	34.33	451 / 472
blood vessel	100%	4875.50	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.73	29 / 29
muscle	100%	5858.27	803 / 803	0%	0	0 / 0
spleen	100%	2190.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	31.55	45 / 45
ureter	0%	0	0 / 0	100%	12.67	1 / 1
adipose	100%	4684.16	1203 / 1204	0%	0	0 / 0
heart	97%	2924.38	831 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	18.56	73 / 80
peripheral blood	55%	1764.62	508 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0001833	Biological process	inner cell mass cell proliferation
GO_0001834	Biological process	trophectodermal cell proliferation
GO_0006366	Biological process	transcription by RNA polymerase II
GO_0030182	Biological process	neuron differentiation
GO_2000434	Biological process	regulation of protein neddylation
GO_0006468	Biological process	protein phosphorylation
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0045116	Biological process	protein neddylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0000338	Biological process	protein deneddylation
GO_0008180	Cellular component	COP9 signalosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003714	Molecular function	transcription corepressor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	COPS2
Protein name	COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) COP9 signalosome subunit 2 COP9 signalosome complex subunit 2
Synonyms	CSN2 TRIP15
Description	FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. .
Accessions	H0YMC2 ENST00000388901.10 [P61201-1] P61201 ENST00000560240.5 B4DIH5 H0YKU5 ENST00000558843.5 ENST00000561248.1 ENST00000299259.10 [P61201-2] ENST00000542928.5 H0YM03

COPS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review