| Name | SCF ubiquitin ligase complex |
| ID | GO_0019005 |
| collection_id | Cellular component |
| Exact synonym | CDL1 complex, CRL1 complex, Cul1-RING ubiquitin ligase complex, SCF complex, Skp1/Cul1/F-box protein complex, cullin-RING ligase 1 |
| Description | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
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| Genes | DMAC2FBXO9TMEM183BPFBXW7SPSB1FBH1FBXL2LRRC29FBXL8TRIM21PRKNFBXL15ARIH1FBXO31FBXL13CKS2CKS1BFBXW4FBXL20FBXO3DAW1FBXL19FBXL6BTRCSKP2SPSB2FBXL21PFBXO48FBXL5NCCRP1SPSB4CUL2FBXW5FBXO38FBXO7FBXW11FBXL16FBXO15FBXO6AMN1CUL1FBXO32FBXL3FBXL12CUL5FBXL18FBXL4SPSB3FBXL7CACYBPFBXO4FBXO39FBXO2FBXO17TMEM183AFBXO27SKP1FBXO44USP47FBXL14FBXO42FBXL17FBXO45CCNFFBXW8FBXO25RBX1 |