FBXL17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008589Biological processregulation of smoothened signaling pathway
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0014033Biological processneural crest cell differentiation
GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0000209Biological processprotein polyubiquitination
GO_0007399Biological processnervous system development
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXL17
Protein nameF-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13)
F-box and leucine rich repeat protein 17
F-box and leucine-rich repeat protein 17
SynonymsFBXO13
FBX13
FBL17
DescriptionFUNCTION: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) . FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome . The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 . The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction . The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). .

AccessionsQ9UF56
ENST00000542267.7 [Q9UF56-1]
ENST00000496714.2
H7C835
A0A6E1XD66