FBXL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045732Biological processpositive regulation of protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0006879Biological processintracellular iron ion homeostasis
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0051537Molecular function2 iron, 2 sulfur cluster binding
GO_0005506Molecular functioniron ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXL5
Protein nameF-box and leucine rich repeat protein 5
F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein)
SynonymsFBL5
FLR1
FBL4
DescriptionFUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2 . The C-terminal domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation . Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation . When intracellular iron levels start rising, the Hr region is stabilized . Additional increases in iron levels facilitate the assembly and incorporation of a redox active [2Fe-2S] cluster in the C-terminal domain . Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquination and degradation . Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1 . Within the nucleus, promotes the ubiquitination of SNAI1; preventing its interaction with DNA and promoting its degradation . Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2 . .

AccessionsENST00000507899.1
ENST00000510802.5
D6R9Y4
ENST00000509314.5
D6RHC3
D6RCR7
ENST00000511441.5
D6RB50
ENST00000412094.6 [Q9UKA1-2]
H0Y9Y0
D6RBW7
D6RED6
ENST00000503196.5
ENST00000515679.1
ENST00000513163.5
ENST00000341285.8 [Q9UKA1-1]
H0YAG2
ENST00000512066.5
Q9UKA1