SKP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0006338Biological processchromatin remodeling
GO_1904668Biological processpositive regulation of ubiquitin protein ligase activity
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0006513Biological processprotein monoubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031519Cellular componentPcG protein complex
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0031467Cellular componentCul7-RING ubiquitin ligase complex
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0140677Molecular functionmolecular function activator activity
GO_0019904Molecular functionprotein domain specific binding
GO_0160072Molecular functionubiquitin ligase complex scaffold activity
GO_0097602Molecular functioncullin family protein binding
GO_0008013Molecular functionbeta-catenin binding
GO_1990444Molecular functionF-box domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSKP1
Protein nameS-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19skp1)
S-phase kinase associated protein 1
SynonymsSKP1A
OCP2
TCEB1L
EMC19
DescriptionFUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 . SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. .

FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. .; FUNCTION: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. .

AccessionsF8W8N3
ENST00000522855.5 [P63208-1]
ENST00000522552.5 [P63208-2]
ENST00000521216.5
ENST00000523966.5
P63208
E7ERH2
E5RHM3
ENST00000523359.1
ENST00000519321.5
ENST00000519054.5
ENST00000517625.5 [P63208-1]
ENST00000520417.1
E5RGM4
ENST00000328392.10
E5RK33
E5RJR5
ENST00000353411.11 [P63208-1]
E5RGM3