FBXO38 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0050870Biological processpositive regulation of T cell activation
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0010976Biological processpositive regulation of neuron projection development
GO_0002842Biological processpositive regulation of T cell mediated immune response to tumor cell
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO38
Protein nameF-box only protein 38
FBXO38 protein
SynonymsSP329
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity . Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival . May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). .

AccessionsENST00000296701.10 [Q6PIJ6-3]
Q6AZE0
ENST00000340253.10 [Q6PIJ6-1]
Q6PIJ6
ENST00000513826.1 [Q6PIJ6-3]
A0PJ52
ENST00000394370.7 [Q6PIJ6-2]