FBXO6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXO6 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006986Biological processresponse to unfolded protein
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0006281Biological processDNA repair
GO_0006508Biological processproteolysis
GO_0036503Biological processERAD pathway
GO_0000077Biological processDNA damage checkpoint signaling
GO_0006516Biological processglycoprotein catabolic process
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0044322Cellular componentendoplasmic reticulum quality control compartment
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO6
Protein nameF-box protein 6
F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)
SynonymsFBG2
FBS2
FBX6
DescriptionFUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. .

AccessionsJ3KQ72
ENST00000376753.9
ENST00000449067.1
Q9NRD1