FBXO3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0006508Biological processproteolysis
GO_0032496Biological processresponse to lipopolysaccharide
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO3
Protein nameF-box protein 3
F-box protein 3 (FBXO3 protein) (cDNA, FLJ79185, highly similar to F-box only protein 3)
F-box only protein 3
F-box protein 3 (cDNA FLJ59154, highly similar to F-box only protein 3)
SynonymshCG_27567
FBX3
DescriptionFUNCTION: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome . In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented . PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation . The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) . The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (By similarity). .

AccessionsENST00000448981.6 [Q9UK99-2]
ENST00000526785.5
ENST00000532927.5
ENST00000530401.5 [Q9UK99-3]
G3V1E0
ENST00000265651.8 [Q9UK99-1]
ENST00000534136.5
E9PL46
ENST00000529137.1
ENST00000532057.5
E9PJM3
Q49AF1
B4E3U2
Q9UK99
ENST00000531080.5