FBXL19 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FBXL19 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXL19 at tissue level.

III. Associated gene sets

GO_0006482Biological processprotein demethylation
GO_0006338Biological processchromatin remodeling
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0032452Molecular functionhistone demethylase activity
GO_0045322Molecular functionunmethylated CpG binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene nameFBXL19
Protein nameF-box and leucine rich repeat protein 19 (F-box/LRR-repeat protein 19)
F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19)
F-box and leucine rich repeat protein 19
SynonymsFBL19
DescriptionFUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization . Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner . Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration . Mediates also ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (By similarity). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides . Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (By similarity). .

AccessionsENST00000471231.6
ENST00000566320.2
H3BQP6
H3BVB1
ENST00000427128.5
ENST00000565690.5
H3BPZ0
H7C112
H3BME1
H3BPI8
ENST00000562798.2
ENST00000565939.1
ENST00000562319
H3BTJ3
ENST00000338343.10
ENST00000562319.7 [Q6PCT2-1]
Q6PCT2