FBXL13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005813Cellular componentcentrosome
GO_0031514Cellular componentmotile cilium
GO_0005829Cellular componentcytosol

IV. Literature review

[source]
Gene nameFBXL13
Protein nameF-box and leucine-rich repeat protein 13, isoform CRA_b (FBXL13 protein)
F-box and leucine-rich repeat protein 13 (Dynein regulatory complex subunit 6) (F-box/LRR-repeat protein 13)
F-box and leucine rich repeat protein 13
SynonymsDRC6
hCG_1646251
FBL13
DescriptionFUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity . .

AccessionsA0A8Q3WK56
ENST00000440067.4
E7ERH8
ENST00000313221.8 [Q8NEE6-1]
Q8NEE6
ENST00000379305.7
ENST00000456695.6
C9JI88
ENST00000694871.1
ENST00000471074.1
A0A8V8NC12
Q4G192
A0A8Q3WLA0
A0A8Q3WK79
ENST00000448002.6
ENST00000694870.1
A0A8Q3WKA2
ENST00000477915.5
ENST00000455112.7