SPSB4 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	4 studies	35% ± 13%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPSB4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	91%	119.82	2401 / 2642	99%	13.78	695 / 705
pancreas	100%	979.38	328 / 328	42%	0.91	75 / 178
lung	87%	89.12	504 / 578	17%	1.20	196 / 1155
adrenal gland	29%	41.76	75 / 258	71%	8.05	163 / 230
heart	99%	261.48	849 / 861	0%	0	0 / 0
spleen	95%	332.24	230 / 241	0%	0	0 / 0
kidney	66%	58.92	59 / 89	11%	1.00	96 / 901
esophagus	50%	61.98	725 / 1445	26%	1.11	47 / 183
breast	31%	22.59	144 / 459	26%	0.86	287 / 1118
muscle	53%	60.67	428 / 803	0%	0	0 / 0
intestine	46%	33.06	446 / 966	5%	0.22	26 / 527
adipose	51%	55.32	613 / 1204	0%	0	0 / 0
bladder	33%	26.33	7 / 21	8%	0.69	39 / 504
uterus	5%	2.74	8 / 170	34%	2.47	157 / 459
ovary	2%	1.18	4 / 180	34%	1.98	147 / 430
thymus	23%	12.38	147 / 653	13%	0.58	78 / 605
blood vessel	25%	15.21	332 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	24%	2.46	11 / 45
skin	14%	13.79	259 / 1809	8%	0.43	39 / 472
prostate	20%	16.18	48 / 245	1%	0.08	4 / 502
liver	16%	9.11	36 / 226	4%	0.09	16 / 406
stomach	16%	8.17	57 / 359	3%	0.12	10 / 286
eye	0%	0	0 / 0	1%	0.02	1 / 80
peripheral blood	0%	0.16	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1902916	Biological process	positive regulation of protein polyubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0016567	Biological process	protein ubiquitination
GO_0035556	Biological process	intracellular signal transduction
GO_0048511	Biological process	rhythmic process
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0042752	Biological process	regulation of circadian rhythm
GO_0019005	Cellular component	SCF ubiquitin ligase complex
GO_0005829	Cellular component	cytosol
GO_1990756	Molecular function	ubiquitin-like ligase-substrate adaptor activity
GO_0005515	Molecular function	protein binding

Gene name	SPSB4
Protein name	SplA/ryanodine receptor domain and SOCS box containing 4 SPRY domain-containing SOCS box protein 4 (SSB-4)
Synonyms	SSB4
Description	FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 . Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 . Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 . .
Accessions	ENST00000508126.1 H0Y8T2 Q96A44 ENST00000310546.3

SPSB4 report