CUL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0008283Biological processcell population proliferation
GO_0009887Biological processanimal organ morphogenesis
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0006513Biological processprotein monoubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031461Cellular componentcullin-RING ubiquitin ligase complex
GO_1990452Cellular componentParkin-FBXW7-Cul1 ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005634Cellular componentnucleus
GO_0160072Molecular functionubiquitin ligase complex scaffold activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCUL1
Protein nameCullin 1
Uncharacterized protein CUL1
Cullin-1 (CUL-1)
SynonymshCG_16546
tcag7.516
DescriptionFUNCTION: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins . In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 . SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of CCNE1, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. .

AccessionsENST00000663044.1
Q75MQ1
ENST00000671397.1
ENST00000655324.1
ENST00000663835.1
ENST00000325222.9
A0A590UK34
A0A590UJ56
ENST00000409469.5
A0A590UJ21
ENST00000662716.1
ENST00000671421.1
A0A590UJC4
ENST00000666124.1
A0A590UJA0
A0A590UJ59
ENST00000665936.1
A0A090N7U0
A0A590UJM8
A0A590UJR3
ENST00000656001.1
ENST00000662132.1
ENST00000660013.1
ENST00000660240.1
A0A590UJ50
ENST00000602748.5
ENST00000662670.1
Q13616
A0A590UJ97