Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 30% ± 13% | |
fibroblast | 11 studies | 25% ± 10% | |
microglial cell | 10 studies | 33% ± 13% | |
astrocyte | 10 studies | 29% ± 14% | |
oligodendrocyte | 10 studies | 29% ± 11% | |
glutamatergic neuron | 9 studies | 42% ± 26% | |
macrophage | 9 studies | 28% ± 11% | |
oligodendrocyte precursor cell | 9 studies | 30% ± 15% | |
adipocyte | 9 studies | 26% ± 8% | |
natural killer cell | 8 studies | 18% ± 2% | |
dendritic cell | 8 studies | 26% ± 8% | |
pericyte | 8 studies | 25% ± 10% | |
GABAergic neuron | 8 studies | 44% ± 22% | |
smooth muscle cell | 7 studies | 21% ± 5% | |
monocyte | 6 studies | 21% ± 4% | |
neuron | 6 studies | 36% ± 15% | |
interneuron | 6 studies | 44% ± 22% | |
epithelial cell | 6 studies | 34% ± 15% | |
type II pneumocyte | 6 studies | 22% ± 7% | |
retinal rod cell | 5 studies | 27% ± 12% | |
ciliated cell | 5 studies | 24% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 28% ± 10% | |
type I pneumocyte | 5 studies | 25% ± 7% | |
club cell | 5 studies | 21% ± 9% | |
basal cell | 5 studies | 31% ± 18% | |
classical monocyte | 4 studies | 19% ± 3% | |
granule cell | 4 studies | 23% ± 5% | |
mucosal invariant T cell | 4 studies | 17% ± 1% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 19% ± 4% | |
retinal cone cell | 4 studies | 28% ± 11% | |
lymphocyte | 4 studies | 24% ± 7% | |
abnormal cell | 4 studies | 27% ± 13% | |
T cell | 4 studies | 19% ± 2% | |
hematopoietic precursor cell | 3 studies | 21% ± 4% | |
GABAergic interneuron | 3 studies | 28% ± 5% | |
glial cell | 3 studies | 20% ± 3% | |
progenitor cell | 3 studies | 24% ± 2% | |
retinal ganglion cell | 3 studies | 23% ± 3% | |
naive B cell | 3 studies | 17% ± 2% | |
amacrine cell | 3 studies | 25% ± 7% | |
retina horizontal cell | 3 studies | 25% ± 10% | |
cardiac muscle cell | 3 studies | 17% ± 0% | |
mesothelial cell | 3 studies | 21% ± 2% | |
myeloid cell | 3 studies | 19% ± 1% | |
glycinergic amacrine cell | 3 studies | 20% ± 4% | |
hepatocyte | 3 studies | 46% ± 22% | |
muscle cell | 3 studies | 31% ± 22% | |
connective tissue cell | 3 studies | 16% ± 1% | |
ependymal cell | 3 studies | 31% ± 17% | |
alveolar macrophage | 3 studies | 27% ± 10% | |
goblet cell | 3 studies | 28% ± 14% | |
transit amplifying cell | 3 studies | 38% ± 27% | |
mast cell | 3 studies | 19% ± 0% | |
mural cell | 3 studies | 28% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 4844.03 | 459 / 459 | 100% | 71.65 | 1118 / 1118 |
esophagus | 100% | 5154.53 | 1445 / 1445 | 100% | 56.52 | 183 / 183 |
liver | 100% | 2995.68 | 226 / 226 | 100% | 47.45 | 406 / 406 |
ovary | 100% | 4186.77 | 180 / 180 | 100% | 51.68 | 430 / 430 |
stomach | 100% | 3674.39 | 359 / 359 | 100% | 57.21 | 286 / 286 |
uterus | 100% | 4686.90 | 170 / 170 | 100% | 65.17 | 459 / 459 |
thymus | 100% | 4101.65 | 653 / 653 | 100% | 61.84 | 604 / 605 |
lung | 100% | 3998.58 | 577 / 578 | 100% | 63.15 | 1155 / 1155 |
intestine | 100% | 4944.02 | 966 / 966 | 100% | 60.14 | 526 / 527 |
bladder | 100% | 5344.33 | 21 / 21 | 100% | 62.40 | 503 / 504 |
prostate | 100% | 4211.82 | 245 / 245 | 100% | 53.40 | 501 / 502 |
kidney | 100% | 2665.96 | 89 / 89 | 99% | 48.21 | 896 / 901 |
brain | 99% | 3581.37 | 2626 / 2642 | 100% | 67.88 | 705 / 705 |
skin | 100% | 4730.83 | 1809 / 1809 | 99% | 79.46 | 469 / 472 |
adrenal gland | 100% | 3962.01 | 258 / 258 | 99% | 55.51 | 228 / 230 |
pancreas | 98% | 1739.63 | 320 / 328 | 99% | 51.74 | 177 / 178 |
adipose | 100% | 4960.75 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5218.13 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 72.53 | 29 / 29 |
muscle | 100% | 7586.35 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4048.24 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 55.66 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 40.33 | 1 / 1 |
heart | 97% | 3245.48 | 839 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 37.11 | 74 / 80 |
peripheral blood | 76% | 2056.05 | 704 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
GO_0016567 | Biological process | protein ubiquitination |
GO_0008283 | Biological process | cell population proliferation |
GO_0009887 | Biological process | animal organ morphogenesis |
GO_0097193 | Biological process | intrinsic apoptotic signaling pathway |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0006513 | Biological process | protein monoubiquitination |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
GO_0005886 | Cellular component | plasma membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0031461 | Cellular component | cullin-RING ubiquitin ligase complex |
GO_1990452 | Cellular component | Parkin-FBXW7-Cul1 ubiquitin ligase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
GO_0005634 | Cellular component | nucleus |
GO_0160072 | Molecular function | ubiquitin ligase complex scaffold activity |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | CUL1 |
Protein name | Cullin 1 Uncharacterized protein CUL1 Cullin-1 (CUL-1) |
Synonyms | hCG_16546 tcag7.516 |
Description | FUNCTION: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins . In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 . SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of CCNE1, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. . |
Accessions | ENST00000663044.1 Q75MQ1 ENST00000671397.1 ENST00000655324.1 ENST00000663835.1 ENST00000325222.9 A0A590UK34 A0A590UJ56 ENST00000409469.5 A0A590UJ21 ENST00000662716.1 ENST00000671421.1 A0A590UJC4 ENST00000666124.1 A0A590UJA0 A0A590UJ59 ENST00000665936.1 A0A090N7U0 A0A590UJM8 A0A590UJR3 ENST00000656001.1 ENST00000662132.1 ENST00000660013.1 ENST00000660240.1 A0A590UJ50 ENST00000602748.5 ENST00000662670.1 Q13616 A0A590UJ97 |