Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| extravillous trophoblast | 3 studies | 26% ± 8% | |
| placental villous trophoblast | 3 studies | 29% ± 9% | |
| GABAergic neuron | 3 studies | 25% ± 4% | |
| glutamatergic neuron | 3 studies | 39% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 27% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 100% | 886.05 | 170 / 170 | 98% | 10.79 | 449 / 459 |
| bladder | 100% | 744.62 | 21 / 21 | 97% | 9.29 | 489 / 504 |
| esophagus | 100% | 840.95 | 1441 / 1445 | 97% | 10.32 | 177 / 183 |
| ovary | 99% | 760.63 | 179 / 180 | 97% | 6.97 | 416 / 430 |
| intestine | 100% | 736.63 | 966 / 966 | 95% | 6.87 | 499 / 527 |
| stomach | 98% | 483.94 | 353 / 359 | 96% | 7.55 | 274 / 286 |
| brain | 100% | 603.50 | 2633 / 2642 | 92% | 4.17 | 646 / 705 |
| breast | 100% | 670.15 | 459 / 459 | 91% | 5.26 | 1016 / 1118 |
| lung | 97% | 612.85 | 562 / 578 | 91% | 8.77 | 1056 / 1155 |
| skin | 100% | 1302.42 | 1809 / 1809 | 79% | 4.43 | 373 / 472 |
| adrenal gland | 99% | 696.35 | 255 / 258 | 80% | 3.94 | 184 / 230 |
| liver | 100% | 924.47 | 225 / 226 | 67% | 3.49 | 270 / 406 |
| pancreas | 98% | 392.25 | 323 / 328 | 65% | 3.24 | 115 / 178 |
| prostate | 100% | 689.94 | 245 / 245 | 56% | 1.78 | 282 / 502 |
| kidney | 99% | 395.10 | 88 / 89 | 44% | 1.39 | 396 / 901 |
| thymus | 100% | 586.92 | 651 / 653 | 40% | 1.65 | 245 / 605 |
| spleen | 100% | 1037.39 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 9.48 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.86 | 1 / 1 |
| adipose | 100% | 761.67 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 461.07 | 1324 / 1335 | 0% | 0 | 0 / 0 |
| heart | 91% | 276.25 | 785 / 861 | 0% | 0 | 0 / 0 |
| muscle | 84% | 197.49 | 675 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 80% | 751.22 | 741 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 4.06 | 22 / 29 |
| eye | 0% | 0 | 0 / 0 | 20% | 0.48 | 16 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| GO_0045087 | Biological process | innate immune response |
| GO_0051607 | Biological process | defense response to virus |
| GO_1902916 | Biological process | positive regulation of protein polyubiquitination |
| GO_0033148 | Biological process | positive regulation of intracellular estrogen receptor signaling pathway |
| GO_0070936 | Biological process | protein K48-linked ubiquitination |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0070534 | Biological process | protein K63-linked ubiquitination |
| GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
| GO_0000086 | Biological process | G2/M transition of mitotic cell cycle |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
| GO_0005634 | Cellular component | nucleus |
| GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SKP2 |
| Protein name | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) S-phase kinase associated protein 2 (S-phase kinase-associated protein 2 (P45), isoform CRA_b) S-phase kinase associated protein 2 |
| Synonyms | FBXL1 hCG_36893 |
| Description | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription . Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 . Degradation of TAL1 also requires STUB1 . Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 . Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration . .; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. . |
| Accessions | Q13309 A0A7I2YQB7 ENST00000676559.1 ENST00000678537.1 D6RAG5 ENST00000513151.6 ENST00000513263.2 D6RF40 ENST00000509692.5 D6R9R7 ENST00000677911.1 A0A7P0S4R7 ENST00000679015.1 ENST00000678270.1 ENST00000508514.5 A0A7I2V2J7 ENST00000677537.1 ENST00000274255.11 [Q13309-1] A0A7I2V3U1 ENST00000678948.1 D6RHY6 A0A0A0MTL5 ENST00000677886.1 ENST00000274254.9 [Q13309-2] ENST00000678580.1 A0A7I2V5B8 A0A7I2YQH6 ENST00000678260.1 H0Y9I9 ENST00000546211.6 ENST00000620197.5 ENST00000677984.1 A0A7I2V413 A0A7I2YQC7 ENST00000504386.1 |
