TRIM21 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM21 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM21 at tissue level.

III. Associated gene sets

GO_0090086Biological processnegative regulation of protein deubiquitination
GO_0016567Biological processprotein ubiquitination
GO_0062197Biological processcellular response to chemical stress
GO_0000209Biological processprotein polyubiquitination
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0010498Biological processproteasomal protein catabolic process
GO_0032092Biological processpositive regulation of protein binding
GO_0032880Biological processregulation of protein localization
GO_0051865Biological processprotein autoubiquitination
GO_0070269Biological processpyroptotic inflammatory response
GO_0046598Biological processpositive regulation of viral entry into host cell
GO_0031648Biological processprotein destabilization
GO_0032479Biological processregulation of type I interferon production
GO_0034341Biological processresponse to type II interferon
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045824Biological processnegative regulation of innate immune response
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0035617Biological processstress granule disassembly
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0044790Biological processsuppression of viral release by host
GO_0006513Biological processprotein monoubiquitination
GO_0046596Biological processregulation of viral entry into host cell
GO_0032897Biological processnegative regulation of viral transcription
GO_0045787Biological processpositive regulation of cell cycle
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_1990904Cellular componentribonucleoprotein complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM21
Protein nameTripartite motif containing 21
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
SynonymsSSA1
RNF81
RO52
DescriptionFUNCTION: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2 . Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination . Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes . A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome . Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling . Negatively regulates IFN-beta production post-pathogen recognition by catalyzing polyubiquitin-mediated degradation of IRF3 . Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway . Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages (By similarity). Plays a role in the regulation of the cell cycle progression . Enhances the decapping activity of DCP2 . Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules . At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified . The common feature of these proteins is their ability to bind HY RNAs.2 . Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma . Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy . Regulates also autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability . Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI . During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation . When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity . Mediates 'Lys-63'-linked polyubiquitination of G3BP1 in response to heat shock, leading to stress granule disassembly . .

AccessionsH0YDP8
ENST00000533692.1
ENST00000254436.8 [P19474-1]
P19474